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在存在DNA合成抑制剂的情况下红白血病细胞的分化

Differentiation of erythroleukemic cells in the presence of inhibitors of DNA synthesis.

作者信息

Leder A, Orkin S, Leder P

出版信息

Science. 1975 Nov 28;190(4217):893-4. doi: 10.1126/science.1059262.

DOI:10.1126/science.1059262
PMID:1059262
Abstract

Erythroid differentiation can be readily induced by butyric acid in cultured erythroleukemic cells in the presence of inhibitors of DNA synthesis and in the absence of cell division. This result appears to rule out more complex models for globin gene expression which require gene replication or cell division (or both).

摘要

在DNA合成抑制剂存在且无细胞分裂的情况下，丁酸可在培养的红白血病细胞中轻易诱导红细胞分化。这一结果似乎排除了需要基因复制或细胞分裂（或两者皆需）的更复杂的珠蛋白基因表达模型。

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