Yi Ruiqin, Hongo Yayoi, Fahrenbach Albert C
Earth-Life Science Institute, Tokyo Institute of Technology, 2-12-1-IE-1 Ookayama, Meguro-ku, Tokyo, 152-8550, Japan.
Chem Commun (Camb). 2018 Jan 11;54(5):511-514. doi: 10.1039/c7cc08489g.
We report the syntheses of ribonucleoside 5'-monophosphates activated with imidazole, using a mechanism which relies on the in situ generation of cyanogen chloride from the reaction of cyanide anion with hypochlorous acid. Cyanogen chloride reacts rapidly with imidazole to form diimidazole imine as the major product, a species which affords the activation of ribonucleoside 5'-monophosphates to their 5'-phosphorimidazolides.
我们报道了用咪唑活化的核糖核苷5'-单磷酸的合成方法，该方法依赖于氰化物阴离子与次氯酸反应原位生成氯化氰的机制。氯化氰与咪唑迅速反应，形成二咪唑亚胺作为主要产物，该物质能将核糖核苷5'-单磷酸活化为其5'-磷酰咪唑化物。
