锰(II)促进了具有前生物合理性的非酶 RNA 连接反应。
Manganese(II) promotes prebiotically plausible non-enzymatic RNA ligation reactions.
机构信息
MRC-Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge Biomedical Campus, Cambridge CB2 0QH, UK.
Department of Earth Sciences, University of Cambridge, Downing Street, CB2 3EQ, UK.
出版信息
Chem Commun (Camb). 2024 Jun 20;60(51):6528-6531. doi: 10.1039/d4cc01086h.
Abstract
Using different prebiotically plausible activating reagents, the RNA ligation yield was significantly increased in the presence of Mn(II). The mechanism of the activation reaction has been investigated using 5'-AMP as an analogue.
摘要
使用不同的具有前体合理性的激活试剂，在 Mn(II) 的存在下，RNA 的连接产率显著提高。使用 5'-AMP 作为类似物研究了激活反应的机制。
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