Scottish Centre for Respiratory Research, Ninewells Hospital and Medical School, Dundee, Scotland, DD1 9SY, UK.
Lung. 2018 Feb;196(1):15-18. doi: 10.1007/s00408-017-0079-1. Epub 2017 Dec 20.
Little is known about impulse oscillometry (IOS) in COPD. IOS is an effort independent measure of lung resistance and reactance (compliance). We assessed how frequency dependence of resistance (R) and reactance (X) changed in response to bronchoconstriction with carvedilol followed by long acting beta-agonist (LABA) withdrawal. N = 12 patients with moderate to severe COPD were analysed, who had ≥ 100 ml fall in FEV with carvedilol. Compared to baseline taking ICS/LABA there were 21, 59, and 135% significant changes in resistance at 5 Hz (R5), reactance at 5 Hz (X5), and reactance area (AX), respectively, with carvedilol, while after LABA withdrawal only AX showed a further significant increase to 210% (i.e. reduced compliance). Hence changes in lung compliance rather than resistance play a more important role in the beta-2 receptor-mediated responses in COPD.
关于慢性阻塞性肺疾病（COPD）患者的脉冲振荡法（IOS），人们知之甚少。IOS 是一种不依赖于努力的肺阻力和电抗（顺应性）的测量方法。我们评估了卡维地洛（carvedilol）引起的支气管收缩后，以及长效β-激动剂（LABA）停药后，阻力（R）和电抗（X）对频率的依赖性如何变化。我们分析了 12 名中重度 COPD 患者，这些患者在服用卡维地洛后 FEV 下降了 ≥ 100ml。与使用 ICS/LABA 时相比，卡维地洛治疗时，5Hz 时的阻力（R5）、5Hz 时的电抗（X5）和电抗面积（AX）分别有 21%、59%和 135%的显著变化，而 LABA 停药后，仅 AX 进一步显著增加至 210%（即顺应性降低）。因此，在 COPD 患者的β-2 受体介导的反应中，肺顺应性的变化而不是阻力的变化起着更为重要的作用。
