Department of Psychiatry, University of California, San Diego, San Diego, CA, USA.
Department of Family, Community, and Health Systems, School of Nursing, University of Alabama at Birmingham, Birmingham, AL, USA.
AIDS Behav. 2018 May;22(5):1551-1561. doi: 10.1007/s10461-017-2001-5.
We aimed to characterize successful cognitive aging (SCA) among older HIV-infected (HIV+) and HIV-uninfected (HIV-) adults, and to determine associations with positive psychological factors and health-related quality of life (HRQoL). Ninety-nine HIV+ and 46 HIV- older adults (≥ 50 years) completed measures of neurocognition, positive psychological factors, and HRQoL. Using study-defined SCA criteria (i.e., no cognitive or everyday impairment or major depressive disorder), we compared positive psychological factors and HRQoL across four groups: HIV+/SCA+, HIV+/SCA-, HIV-/SCA+, HIV-/SCA-. SCA was identified in 29% of the HIV+ sample compared to 61% of the HIV- sample (p < 0.01). HIV+/SCA+ participants had higher scores on 8 of 10 measures of positive psychological factors as well as better HRQoL (ps < 0.05) as compared to the HIV+/SCA- group. Furthermore, the HIV+/SCA+ participants had comparable scores on these factors as HIV- adults. Fewer HIV+ than HIV- participants met SCA criteria; however, the level of positive psychological factors among the HIV+/SCA+ group was comparable to the HIV- sample. Our findings present opportunities for interventions to optimize positive psychological factors and potentially improve SCA among older HIV+ adults.
我们旨在描述老年 HIV 感染者（HIV+）和 HIV 阴性者（HIV-）中成功的认知老化（SCA），并确定其与积极的心理因素和健康相关生活质量（HRQoL）之间的关联。99 名 HIV+和 46 名 HIV-老年成年人（≥50 岁）完成了神经认知、积极心理因素和 HRQoL 的评估。根据研究定义的 SCA 标准（即无认知或日常功能障碍或重度抑郁症），我们比较了四个组之间的积极心理因素和 HRQoL：HIV+/SCA+、HIV+/SCA-、HIV-/SCA+、HIV-/SCA-。与 HIV-组相比，HIV+组中有 29%的患者符合 SCA 标准，而 HIV-组中有 61%的患者符合 SCA 标准（p<0.01）。与 HIV+/SCA-组相比，HIV+/SCA+参与者在积极心理因素的 10 项评估中有 8 项得分更高，HRQoL 也更好（p<0.05）。此外，与 HIV-成年人相比，HIV+/SCA+参与者在这些因素上的得分相当。与 HIV-参与者相比，HIV+参与者符合 SCA 标准的人数较少；然而，HIV+/SCA+组的积极心理因素水平与 HIV-组相当。我们的研究结果为干预措施提供了机会，以优化积极的心理因素，并有可能改善老年 HIV+成年人的 SCA。
