Department of Psychiatry (8231), University of California, San Diego, 220 Dickinson St., Suite B, San Diego, CA, 92103, USA,
AIDS Behav. 2014 Jun;18(6):1186-97. doi: 10.1007/s10461-014-0743-x.
Neurocognitive impairments commonly occur and adversely impact everyday functioning in older adults infected with HIV, but little is known about successful cognitive aging (SCA) and its health-related quality of life (HRQoL) correlates. Seventy younger (≤40 years) and 107 older (≥50 years) HIV+ adults, as well as age-matched seronegative comparison groups of younger (N = 48) and older (N = 77) subjects completed a comprehensive battery of neuropsychological, psychiatric, medical, and HRQoL assessments. SCA was operationalized as the absence of both performance-based neurocognitive deficits and self-reported symptoms (SCA-ANDS) as determined by published normative standards. A stair-step decline in SCA-ANDS was observed in accordance with increasing age and HIV serostatus, with the lowest rates of SCA-ANDS found in the older HIV+ group (19 %). In both younger and older HIV+ adults, SCA-ANDS was strongly related to better mental HRQoL. HIV infection has additive adverse effects on SCA, which may play a unique role in mental well-being among HIV-infected persons across the lifespan.
神经认知障碍在感染 HIV 的老年人中很常见，且对日常功能有不良影响，但人们对成功的认知老化（SCA）及其与健康相关的生活质量（HRQoL）的相关性知之甚少。70 名较年轻（≤40 岁）和 107 名较年长（≥50 岁）的 HIV+成年人，以及年龄匹配的年轻（N=48）和年长（N=77）的血清阴性对照组完成了全面的神经心理学、精神病学、医学和 HRQoL 评估。SCA 的定义是根据已发表的标准，不存在基于表现的神经认知缺陷和自我报告的症状（SCA-ANDS）。按照年龄和 HIV 血清状态的增加，SCA-ANDS 呈阶梯式下降，在年龄较大的 HIV+组中发现的 SCA-ANDS 率最低（19%）。在较年轻和较年长的 HIV+成年人中，SCA-ANDS 与更好的心理健康 HRQoL 密切相关。HIV 感染对 SCA 有附加的不良影响，这可能在 HIV 感染者的整个生命周期的心理健康中发挥独特作用。
