Basantsova N Yu, Tibekina L M, Shishkin A N
St. Petersburg State University, St. Petersburg, Russia.
Zh Nevrol Psikhiatr Im S S Korsakova. 2017;117(11):153-160. doi: 10.17116/jnevro2017117111153-160.
The authors consider anatomical/physiological characteristics and a role of different autonomic CNS regions, including insula cortex, amygdala complex, anterior cingulate cortex, ventral medial prefrontal cortex, hypothalamus and epiphysis, involved in the regulation of cardiovascular activity. The damage of these structures, e.g., due to the acute disturbance of cerebral blood circulation, led to arrhythmia, including fatal arrhythmia, in previously intact myocardium; systolic and diastolic dysfunction, ischemic changes considered in the frames of cerebro-cardial syndrome. On the cellular level, the disturbance of autonomic regulation resulted in catechol amine excitotoxicity, oxidative stress and free radical myocardium injury.
作者们探讨了解剖学/生理学特征以及不同自主神经中枢神经系统区域（包括岛叶皮质、杏仁核复合体、前扣带回皮质、腹内侧前额叶皮质、下丘脑和松果体）在心血管活动调节中的作用。这些结构的损伤，例如由于脑血液循环的急性紊乱，会导致先前正常的心肌出现心律失常，包括致命性心律失常；收缩和舒张功能障碍，这在脑心综合征框架内被视为缺血性改变。在细胞水平上，自主调节的紊乱会导致儿茶酚胺兴奋性毒性、氧化应激和自由基对心肌的损伤。
