Acampa Maurizio, Lazzerini Pietro E, Martini Giuseppe
Stroke Unit, Department of Neurological and Neurosensorial Sciences, Azienda Ospedaliera Universitaria Senese, "Santa Maria alle Scotte" General Hospital, Siena, Italy.
Department of Medical Sciences, Surgery and Neurosciences, University of Siena, Siena, Italy.
Front Neurol. 2018 Jun 19;9:469. doi: 10.3389/fneur.2018.00469. eCollection 2018.
Recently, atrial cardiopathy has emerged as possible pathogenic mechanism in cryptogenic stroke and many electrocardiographic (ECG) markers have been proposed in order to detect an altered atrial substrate at an early stage. The autonomic nervous system (ANS) plays a well-known role in determining significant and heterogeneous electrophysiological changes of atrial cardiomyocytes, that promote atrial fibrillation episodes in cardioembolic stroke. Conversely, the role of ANS in atrial cardiopathy and cryptogenic stroke is less known, as well as ANS effects on ECG markers of atrial dysfunction. In this paper, we review the evidence linking ANS dysfunction and atrial cardiopathy as a possible pathogenic factor in cryptogenic stroke.
最近，心房心肌病已成为隐匿性卒中可能的致病机制，并且已经提出了许多心电图（ECG）标志物，以便在早期检测心房基质的改变。自主神经系统（ANS）在决定心房心肌细胞显著且异质性的电生理变化方面发挥着众所周知的作用，这些变化会促进心源性栓塞性卒中时房颤的发作。相反，ANS在心房心肌病和隐匿性卒中中的作用鲜为人知，其对心房功能障碍心电图标志物的影响也是如此。在本文中，我们综述了将ANS功能障碍与心房心肌病联系起来作为隐匿性卒中可能致病因素的证据。
