心脏、肝脏和胰腺MRI-R2*之间缺乏相关性：成人重型β地中海贫血患者队列的长期随访结果 - Suppr

Lack of correlation between heart, liver and pancreas MRI-R2*: Results from long-term follow-up in a cohort of adult β-thalassemia major patients.

作者信息

Pinto Valeria Maria, Bacigalupo Lorenzo, Gianesin Barbara, Balocco Manuela, De Franceschi Lucia, Malagò Roberto, Wood John, Forni Gian Luca

机构信息

Centro della Microcitemia e delle Anemie Congenite, Ospedale Galliera, Genoa, Italy.

Radiology Unit, , Ospedale Galliera, Genoa, Italy.

出版信息

Am J Hematol. 2018 Mar;93(3):E79-E82. doi: 10.1002/ajh.25009. Epub 2018 Jan 9.

DOI:10.1002/ajh.25009

PMID:29265491

Abstract

摘要

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Lack of correlation between heart, liver and pancreas MRI-R2*: Results from long-term follow-up in a cohort of adult β-thalassemia major patients.心脏、肝脏和胰腺MRI-R2*之间缺乏相关性：成人重型β地中海贫血患者队列的长期随访结果

Am J Hematol. 2018 Mar;93(3):E79-E82. doi: 10.1002/ajh.25009. Epub 2018 Jan 9.

The Feasibility of Magnetic Resonance Imaging for Quantification of Liver, Pancreas, Spleen, Vertebral Bone Marrow, and Renal Cortex R2* and Proton Density Fat Fraction in Transfusion-Related Iron Overload.磁共振成像用于量化输血相关铁过载中肝脏、胰腺、脾脏、椎体骨髓及肾皮质的R2*和质子密度脂肪分数的可行性

Turk J Haematol. 2016 Mar 5;33(1):21-7. doi: 10.4274/tjh.2015.0142. Epub 2015 Aug 6.

Methods for noninvasive measurement of tissue iron in Cooley's anemia.库利贫血中组织铁的非侵入性测量方法。

Ann N Y Acad Sci. 2005;1054:358-72. doi: 10.1196/annals.1345.044.

Iron Chelation Therapy as a Modality of Management.铁螯合疗法作为一种治疗方式。

Hematol Oncol Clin North Am. 2018 Apr;32(2):261-275. doi: 10.1016/j.hoc.2017.12.002. Epub 2018 Jan 17.

Pancreatic iron in pediatric transfusion-dependent beta-thalassemia patients: A longitudinal MRI study.儿科输血依赖型β-地中海贫血患者的胰腺铁含量：一项纵向 MRI 研究。

Pediatr Blood Cancer. 2024 May;71(5):e30923. doi: 10.1002/pbc.30923. Epub 2024 Feb 22.

Pancreatic iron overload by T2* MRI in a large cohort of well treated thalassemia major patients: can it tell us heart iron distribution and function?通过T2*磁共振成像评估大量接受良好治疗的重型地中海贫血患者的胰腺铁过载情况：它能否告知我们心脏铁分布及功能？

Am J Hematol. 2015 Sep;90(9):E189-90. doi: 10.1002/ajh.24081.

Pituitary iron and volume predict hypogonadism in transfusional iron overload.垂体铁含量和体积可预测输血性铁过载中的性腺功能减退症。

Am J Hematol. 2012 Feb;87(2):167-71. doi: 10.1002/ajh.22247. Epub 2011 Dec 27.

Correlation of Pancreatic Iron Overload Measured by T2*-Weighted Magnetic Resonance Imaging in Diabetic Patients with β-Thalassemia Major.通过T2*加权磁共振成像测量的糖尿病重型β地中海贫血患者胰腺铁过载的相关性

Hemoglobin. 2017 May;41(3):151-156. doi: 10.1080/03630269.2017.1340306. Epub 2017 Aug 1.

Clinical monitoring and management of complications related to chelation therapy in patients with β-thalassemia.β-地中海贫血患者螯合治疗相关并发症的临床监测与管理。

Expert Rev Hematol. 2016;9(2):151-68. doi: 10.1586/17474086.2016.1126176. Epub 2015 Dec 19.

Endocrinopathies, metabolic disorders, and iron overload in major and intermedia thalassemia: serum ferritin as diagnostic and predictive marker associated with liver and cardiac T2* MRI assessment.重型和中间型地中海贫血中的内分泌病、代谢紊乱及铁过载：血清铁蛋白作为与肝脏和心脏T2*磁共振成像评估相关的诊断和预测标志物

Eur J Haematol. 2015 May;94(5):404-12. doi: 10.1111/ejh.12444. Epub 2014 Oct 18.

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Assessment of the distribution of pancreatic iron deposition in non-transfusion dependent thalassemia.非输血依赖型地中海贫血患者胰腺铁沉积分布的评估

Abdom Radiol (NY). 2025 Jun 23. doi: 10.1007/s00261-025-04995-9.

Risk Factors for Impaired Glucose Metabolism in Transfusion-Dependent Patients with β-Thalassemia: A Single-Center Retrospective Observational Study.输血依赖型β地中海贫血患者糖代谢受损的危险因素：一项单中心回顾性观察研究

Hematol Rep. 2025 Jan 30;17(1):6. doi: 10.3390/hematolrep17010006.

Endocrinopathies in Hemoglobinopathies: What Is the Role of Iron?血红蛋白病中的内分泌病：铁的作用是什么？

Int J Mol Sci. 2023 Nov 13;24(22):16263. doi: 10.3390/ijms242216263.

Mortality and complications in Omani patients with beta-thalassemia major: a long-term follow-up study.阿曼重症β地中海贫血患者的死亡率和并发症：一项长期随访研究。

Acta Biomed. 2023 Aug 3;94(4):e2023191. doi: 10.23750/abm.v94i5.14856.

Longitudinal prospective comparison of pancreatic iron by magnetic resonance in thalassemia patients transfusion-dependent since early childhood treated with combination deferiprone-desferrioxamine vs deferiprone or deferasirox monotherapy.对自幼即依赖输血的地中海贫血患者，采用去铁酮-去铁胺联合治疗与去铁酮或地拉罗司单药治疗，通过磁共振对胰腺铁进行纵向前瞻性比较。

Blood Transfus. 2024 Jan;22(1):75-85. doi: 10.2450/BloodTransfus.485. Epub 2023 Feb 24.

Longitudinal study of ICET-A on glucose tolerance, insulin sensitivity and β-cell secretion in eleven β-thalassemia major patients with mild iron overload.一项关于葡萄糖耐量、胰岛素敏感性和β细胞分泌的十一年纵向研究，研究对象为 11 名β-地中海贫血伴轻度铁过载患者的 ICET-A。

Acta Biomed. 2023 Feb 13;94(1):e2023011. doi: 10.23750/abm.v94i1.14000.

Prospective changes of pancreatic iron in patients with thalassemia major and association with chelation therapy.重型地中海贫血患者胰腺铁的前瞻性变化及其与螯合治疗的关系。

Blood Adv. 2023 May 23;7(10):2237-2240. doi: 10.1182/bloodadvances.2022008805.

Renal function in β-thalassemia major patients treated with two different iron-chelation regimes.β-重型地中海贫血患者接受两种不同铁螯合治疗方案的肾功能。

BMC Nephrol. 2021 Dec 20;22(1):418. doi: 10.1186/s12882-021-02630-5.

Risk factors for endocrine complications in transfusion-dependent thalassemia patients on chelation therapy with deferasirox: a risk assessment study from a multi-center nation-wide cohort.依赖输血的地中海贫血患者在使用去铁酮螯合治疗时发生内分泌并发症的风险因素：一项来自多中心全国队列的风险评估研究。

Haematologica. 2022 Feb 1;107(2):467-477. doi: 10.3324/haematol.2020.272419.

Management of Iron Overload in Beta-Thalassemia Patients: Clinical Practice Update Based on Case Series.β-地中海贫血患者铁过载的管理：基于病例系列的临床实践更新。

Int J Mol Sci. 2020 Nov 20;21(22):8771. doi: 10.3390/ijms21228771.

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Lack of correlation between heart, liver and pancreas MRI-R2*: Results from long-term follow-up in a cohort of adult β-thalassemia major patients.

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