[造血干细胞分化与胸腺功能状态之间的关系]
[Relationship between hematopoietic stem differentiation and the functional state of the thymus].
作者信息
Khaitov R M, Riabova L V
出版信息
Ontogenez. 1978;9(4):406-11.
The direction of differentiation of the stem cells with respect to the physiological activity of thymus determined by the age of an animal was studied by means of histological analysis of hemopoietic colonies in the spleen of lethally irradiated mice. The immaturity of thymus of its involution are characterized by the inhibition of differentiation of the stem cell along the granuloid path. An analysis of the data on differentiation of the stem cells in mice of different age, as well as in thymectomized mice allows to draw a conclusion that the process of differentiation of the hemopoietic stem cells is thymus-dependent.
通过对受致死剂量照射小鼠脾脏中造血集落进行组织学分析，研究了动物年龄所决定的干细胞分化方向与胸腺生理活性之间的关系。胸腺不成熟或退化的特征在于干细胞沿粒细胞途径的分化受到抑制。对不同年龄小鼠以及胸腺切除小鼠的干细胞分化数据进行分析后可以得出结论，造血干细胞的分化过程依赖于胸腺。
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