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[胸腺细胞对造血干细胞放射敏感性及分化趋势的影响]

[Effect of thymus cells on the radiosensitivity and differentiation trends of hematopoietic stem cells].

作者信息

Shvets V N

出版信息

Tsitologiia. 1976 Oct;18(10):1254-8.

PMID:15337
Abstract

A stimulating influence of thymus cells on the capability of irradiated (from 100 to 500 r) bone marrow of mice of producing colonies in spleen of syngenous recipient has been proven. The intensification of colony formation involves an increased radioresistance of stem cells. It is supposed that radioresistant thymus cells have a stimulating effect. Thymus cells exert their influence not only to the rate of survival of stem cells proliferating in the bone marrow of femur, but also increase their erythropoetic potention.

摘要

已证实胸腺细胞对受辐照(100至500伦琴)的小鼠骨髓在同基因受体脾脏中产生集落的能力具有刺激作用。集落形成的增强涉及干细胞放射抗性的增加。据推测,放射抗性胸腺细胞具有刺激作用。胸腺细胞不仅对在股骨骨髓中增殖的干细胞的存活率产生影响,而且还提高其红细胞生成潜能。

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