Flesch Aline Taborda, Tonial Stael T, Contu Paulo DE Carvalho, Damin Daniel C
- Federal University of Rio Grande do Sul, Post-Graduation Program in Surgical Sciences, Porto Alegre, RS, Brazil.
Rev Col Bras Cir. 2017 Nov-Dec;44(6):567-573. doi: 10.1590/0100-69912017006004.
to evaluate the effect of perioperative administration of symbiotics on the incidence of surgical wound infection in patients undergoing surgery for colorectal cancer.
We conducted a randomized clinical trial with colorectal cancer patients undergoing elective surgery, randomly assigned to receive symbiotics or placebo for five days prior to the surgical procedure and for 14 days after surgery. We studied 91 patients, 49 in the symbiotics group (Lactobacillus acidophilus 108 to 109 CFU, Lactobacillus rhamnosus 108 to 109 CFU, Lactobacillus casei 108 to 109 CFU, Bifi dobacterium 108 to 109 CFU and fructo-oligosaccharide (FOS) 6g) and 42 in the placebo group.
surgical site infection occurred in one (2%) patient in the symbiotics group and in nine (21.4%) patients in the control group (p=0.002). There were three cases of intraabdominal abscess and four cases of pneumonia in the control group, whereas we observed no infections in patients receiving symbiotics (p=0.001).
the perioperative administration of symbiotics significantly reduced postoperative infection rates in patients with colorectal cancer. Additional studies are needed to confirm the role of symbiotics in the surgical treatment of colorectal cancer.
评估围手术期给予合生元对接受结直肠癌手术患者手术伤口感染发生率的影响。
我们对接受择期手术的结直肠癌患者进行了一项随机临床试验，随机分配患者在手术前5天和手术后14天接受合生元或安慰剂。我们研究了91例患者，合生元组49例（嗜酸乳杆菌10⁸至10⁹CFU、鼠李糖乳杆菌10⁸至10⁹CFU、干酪乳杆菌10⁸至10⁹CFU、双歧杆菌10⁸至10⁹CFU和低聚果糖（FOS）6g），安慰剂组42例。
合生元组1例（2%）患者发生手术部位感染，对照组9例（21.4%）患者发生手术部位感染（p = 0.002）。对照组有3例腹腔内脓肿和4例肺炎，而接受合生元的患者未观察到感染（p = 0.001）。
围手术期给予合生元可显著降低结直肠癌患者的术后感染率。需要进一步研究以证实合生元在结直肠癌手术治疗中的作用。
