Pharmaceutical Department, The Second Affiliated Hospital of Dalian Medical University, Dalian, China.
Department of Laboratory Medicine, The Second Affiliated Hospital of Dalian Medical University, Dalian, China.
Int Wound J. 2024 Apr;21(4):e14838. doi: 10.1111/iwj.14838.
Wound infection is a serious complication that impacts the prognosis of patients after colorectal surgery (CS). Probiotics and synbiotics (Pro and Syn) are live bacteria that produce bacteriostatic agents in the intestinal system and have a positive effect on postoperative wound infections. The purpose of this study was to evaluate the effect of Pro and Syn on complications of wound infection after CS. In November 2023, we searched relevant clinical trial reports from Pubmed, Cochrane Library, and Embase databases and screened the retrieved reports, extracted data, and finally analysed the data by using RevMan 5.3. A total of 12 studies with 1567 patients were included in the study. Pro and Syn significantly reduced total infection (OR, 0.44; 95% CI, 0.35, 0.56; p < 0.00001), surgical incision site infection (SSI) (OR, 0.61; 95% CI, 0.45, 0.81; p = 0.002), pneumonia (OR, 0.43; 95% CI, 0.25, 0.72; p = 0.001), urinary tract infection (OR, 0.28; 95% CI, 0.14, 0.56; p = 0.0003), and Pro and Syn did not reduce anastomotic leakage after colorectal surgery (OR, 0.84; 95% CI, 0.50, 1.41; p = 0.51). Pro and Syn can reduce postoperative wound infections in patients with colorectal cancer, which benefits patients' postoperative recovery.
伤口感染是结直肠手术后（CS）患者预后的严重并发症。益生菌和合生剂（Pro 和 Syn）是在肠道系统中产生抑菌剂并对术后伤口感染有积极影响的活菌。本研究旨在评估 Pro 和 Syn 对 CS 后伤口感染并发症的影响。2023 年 11 月，我们检索了 Pubmed、Cochrane Library 和 Embase 数据库中的相关临床试验报告，并筛选了检索到的报告，提取数据，最后使用 RevMan 5.3 分析数据。共有 12 项研究纳入了 1567 名患者。Pro 和 Syn 显著降低了总感染（OR，0.44；95%CI，0.35，0.56；p<0.00001）、手术切口部位感染（SSI）（OR，0.61；95%CI，0.45，0.81；p=0.002）、肺炎（OR，0.43；95%CI，0.25，0.72；p=0.001）、尿路感染（OR，0.28；95%CI，0.14，0.56；p=0.0003），但 Pro 和 Syn 并未降低结直肠手术后的吻合口漏（OR，0.84；95%CI，0.50，1.41；p=0.51）。Pro 和 Syn 可减少结直肠癌患者术后伤口感染，有利于患者术后恢复。
