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新加坡一所三级精神病院首发精神病患者失眠的患病率、相关因素和结局。

Prevalence, correlates and outcomes of insomnia in patients with first episode psychosis from a tertiary psychiatric institution in Singapore.

机构信息

Research Division, Institute of Mental Health, Singapore.

Research Division, Institute of Mental Health, Singapore.

出版信息

Gen Hosp Psychiatry. 2018 Mar-Apr;51:15-21. doi: 10.1016/j.genhosppsych.2017.11.009. Epub 2017 Nov 24.

Abstract

OBJECTIVES

The study aimed to evaluate the prevalence of insomnia in patients with first episode psychosis (FEP) and to explore the relationship between insomnia and socio-demographic and clinical variables as well as quality of life (QOL) and functioning in Singapore.

METHODS

Data on sleep, smoking, alcohol habits, QOL and socio-demographics were collected from 280 FEP patients who were enrolled in the Early Psychosis Intervention Programme (EPIP) within 3months of joining the programme. Multiple logistic regression analyses were performed to determine the socio-demographic and clinical correlates of insomnia. The association of insomnia with QOL as well as functioning was examined using multiple linear regression analyses.

RESULTS

The prevalence of clinical insomnia was 22.6%. Older age and higher dosage of antipsychotic medication were significantly associated with a lower risk of insomnia while hazardous alcohol use, current smoking and a longer duration of untreated psychosis were significantly associated with a higher risk of insomnia. Insomnia was associated with significant decreases in all QOL domains assessed in the study even after adjusting for confounders.

CONCLUSIONS

FEP patients with insomnia must be screened for hazardous alcohol use and smoking. Patients must be referred concurrently for treatment of insomnia, smoking cessation as well as brief intervention for hazardous alcohol use when needed.

摘要

目的

本研究旨在评估首发精神病(FEP)患者的失眠症患病率,并探讨失眠症与新加坡社会人口统计学和临床变量以及生活质量(QOL)和功能的关系。

方法

从参加早期精神病干预计划(EPIP)的 280 名 FEP 患者中收集了睡眠、吸烟、饮酒习惯、QOL 和社会人口统计学数据,这些患者在加入计划后的 3 个月内入组。采用多元逻辑回归分析确定失眠的社会人口统计学和临床相关性。采用多元线性回归分析检验失眠与 QOL 以及功能的关联。

结果

临床失眠症的患病率为 22.6%。年龄较大和抗精神病药物剂量较高与失眠风险降低显著相关,而危险饮酒、当前吸烟和未治疗精神病持续时间较长与失眠风险增加显著相关。即使在调整了混杂因素后,失眠症与所有研究评估的 QOL 领域的显著下降相关。

结论

必须对失眠症的 FEP 患者进行危险饮酒和吸烟筛查。必须同时为失眠症患者、戒烟以及需要时的危险饮酒简短干预提供治疗。

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