靶向疟原虫蛋白酶以阻断疟原虫逃避和入侵。

Targeting Plasmodium Proteases to Block Malaria Parasite Escape and Entry.

机构信息

Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, 651 Huntington Avenue, FXB, Room 202, Boston, Massachusetts 02115, USA.

出版信息

Trends Parasitol. 2018 Feb;34(2):95-97. doi: 10.1016/j.pt.2017.11.012. Epub 2017 Dec 18.

DOI:10.1016/j.pt.2017.11.012

PMID:29269028

Abstract

Proliferation of malaria parasites in a host requires mechanisms to spread between red blood cells (RBCs). We discuss here the implications for biology and antimalarial drug development of companion studies that establish the requirement of two Plasmodium spp. proteases of the plasmepsin family in parasite egress from, and invasion into, RBCs.

摘要

疟原虫在宿主中的繁殖需要在红细胞（RBC）之间传播的机制。我们在这里讨论了伴随研究的生物学和抗疟药物开发的意义，这些研究确定了疟原虫属两种朊病毒家族蛋白酶在寄生虫从 RBC 中逸出和侵入 RBC 中的必要性。