1型自身免疫性胰腺炎患者中与IgG4相关硬化性胆管炎相关的阻塞性黄疸掩盖的自身免疫性溶血性贫血：一例报告及文献复习
Autoimmune Hemolytic Anemia Obscured by the Obstructive Jaundice Associated with IgG4-related Sclerosing Cholangitis in a Patient with Type 1 Autoimmune Pancreatitis: A Case Report and Review of the Literature.
作者信息
Yoshida Michihiro, Marumo Yoshiaki, Naitoh Itaru, Hayashi Kazuki, Miyabe Katsuyuki, Nishi Yuji, Fujita Yasuaki, Jinno Naruomi, Hori Yasuki, Natsume Makoto, Kato Akihisa, Iida Shinsuke, Joh Takashi
机构信息
Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, Japan.
Department of Hematology and Oncology, Nagoya City University Graduate School of Medical Sciences, Japan.
出版信息
Intern Med. 2018 Jun 15;57(12):1725-1732. doi: 10.2169/internalmedicine.9818-17. Epub 2017 Dec 21.
Type 1 autoimmune pancreatitis (AIP) is a pancreatic manifestation of IgG4-retated disease that is often associated with IgG4-related sclerosing cholangitis (IgG4-SC). Autoimmune hemolytic anemia (AIHA) is an immune-related disease that causes hemolytic anemia. Although type 1 AIP/IgG4-SC and AIHA have a shared etiology as a presumed autoimmune disease, they rarely overlap, and their association has not been clarified. Secondary AIHA might not be diagnosed appropriately because the obstructive jaundice observed in type 1 AIP/IgG4-SC can obscure the presence of hemolytic jaundice. We herein report a case of type 1 AIP/IgG4-SC overlapping with secondary AIHA along with a review of the literature.
1型自身免疫性胰腺炎（AIP）是IgG4相关性疾病的一种胰腺表现，常与IgG4相关性硬化性胆管炎（IgG4-SC）相关。自身免疫性溶血性贫血（AIHA）是一种导致溶血性贫血的免疫相关疾病。虽然1型AIP/IgG4-SC和AIHA作为一种推测的自身免疫性疾病有共同的病因，但它们很少重叠，且它们之间的关联尚未明确。由于在1型AIP/IgG4-SC中观察到的梗阻性黄疸可能掩盖溶血性黄疸的存在，继发性AIHA可能无法得到恰当诊断。我们在此报告一例1型AIP/IgG4-SC与继发性AIHA重叠的病例，并对相关文献进行综述。
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