异稻瘟净和植物甾醇对喂食饱和脂肪饮食大鼠血清脂质及脂肪组织的影响。

Effects of isoprothiolane and phytosterol on serum lipids and adipose tissue of rats given saturated fat diet.

作者信息

Katamoto H, Kurihara S, Shimada Y

出版信息

Nihon Juigaku Zasshi. 1989 Feb;51(1):119-27. doi: 10.1292/jvms1939.51.119.

DOI:10.1292/jvms1939.51.119

Abstract

Rats received hardened-tallow (HT) diet continuously for 18 weeks. After 8 weeks of feeding, isoprothiolane (50 mg/kg) or phytosterol (20 mg/kg) was administered orally to the rats once a day consecutively for 10 weeks. In the rats given isoprothiolane, serum high density lipoprotein (HDL) phospholipid concentration increased. Decreased serum very low density lipoprotein (VLDL) cholesterol concentration was seen in the rats given phytosterol. Isoprothiolane increased the level of palmitoleic acid (16:1), while phytosterol increased the level of palmitic acid (16:0) in phospholipid of adipose tissue. In the frozen tissue sections, the multiple crystals were seen in fat cells of the rats fed HT diet. Less crystals were seen in the rats given either drug when compared with the rats fed HT diet without drug.

摘要

大鼠连续18周接受硬化牛油（HT）饮食。喂食8周后，异稻瘟净（50毫克/千克）或植物甾醇（20毫克/千克）连续10天每天口服给药一次。在给予异稻瘟净的大鼠中，血清高密度脂蛋白（HDL）磷脂浓度升高。给予植物甾醇的大鼠血清极低密度脂蛋白（VLDL）胆固醇浓度降低。异稻瘟净增加了棕榈油酸（16:1）的水平，而植物甾醇增加了脂肪组织磷脂中棕榈酸（16:0）的水平。在冷冻组织切片中，喂食HT饮食的大鼠脂肪细胞中可见多个晶体。与未给药的喂食HT饮食的大鼠相比，给予任何一种药物的大鼠中晶体较少。