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本文引用的文献

1
Inhibition of HSF2 SUMOylation via MEL18 upregulates IGF-IIR and leads to hypertension-induced cardiac hypertrophy.通过 MEL18 抑制 HSF2 的 SUMOylation，上调 IGF-IIR，导致高血压诱导的心脏肥大。
Int J Cardiol. 2018 Apr 15;257:283-290. doi: 10.1016/j.ijcard.2017.10.102. Epub 2017 Nov 10.
2
p53-mediated miR-18 repression activates HSF2 for IGF-IIR-dependent myocyte hypertrophy in hypertension-induced heart failure.p53介导的miR-18抑制激活HSF2，以促进高血压性心力衰竭中依赖IGF-IIR的心肌细胞肥大。
Cell Death Dis. 2017 Aug 10;8(8):e2990. doi: 10.1038/cddis.2017.320.
3
Lipopolysaccharide-promoted proliferation of Caco-2 cells is mediated by c-Src induction and ERK activation.脂多糖促进的Caco-2细胞增殖是由c-Src诱导和ERK激活介导的。
Biomedicine (Taipei). 2015;5(1):5. doi: 10.7603/s40681-015-0005-x. Epub 2015 Feb 2.
4
ANG II promotes IGF-IIR expression and cardiomyocyte apoptosis by inhibiting HSF1 via JNK activation and SIRT1 degradation.血管紧张素II通过激活JNK和降解SIRT1抑制热休克因子1，从而促进胰岛素样生长因子-II受体表达和心肌细胞凋亡。
Cell Death Differ. 2014 Aug;21(8):1262-74. doi: 10.1038/cdd.2014.46. Epub 2014 May 2.

支持血管紧张素II激活MEL18使HSF2去SUMO化以导致高血压相关心力衰竭的数据。

Data supporting the angiotensin II activates MEL18 to deSUMOylate HSF2 for hypertension-related heart failure.

作者信息

Huang Chih-Yang, Kuo Chia-Hua, Pai Pei-Ying, Ho Tsung-Jung, Lin Yueh-Min, Chen Ray-Jade, Tsai Fuu-Jen, Vijaya Padma V, Kuo Wei-Wen, Huang Chih-Yang

机构信息

Translation Research Core, China Medical University Hospital, China Medical University, Taichung, Taiwan.

Department of Sports Sciences, University of Taipei, Taipei, Taiwan.

出版信息

Data Brief. 2017 Nov 20;16:521-526. doi: 10.1016/j.dib.2017.11.040. eCollection 2018 Feb.

DOI:10.1016/j.dib.2017.11.040
PMID:29270451
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5734702/
Abstract

In association with the published article "Inhibition of HSF2 SUMOylation MEL18 upregulates IGF-IIR and leads to hypertension-induced cardiac hypertrophy" (Huang et al., 2017) [1], this data article contains information about deSUMOylation of HSF2 on lysine 82 on angiotensin II (ANG II) -induced cardiac hypertrophy, which is mediated by MEL18. Isolated adult human whole heart tissue showed MEL18-mediated HSF2-IGF-IIR pathway is upregulated in hypertension human heart, compared to health human heart.

摘要

与已发表的文章《抑制HSF2的SUMO化通过MEL18上调IGF-IIR并导致高血压诱导的心脏肥大》（Huang等人，2017年）[1]相关，本数据文章包含有关在血管紧张素II（ANG II）诱导的心脏肥大中，MEL18介导的赖氨酸82位点HSF2去SUMO化的信息。与健康人心脏相比，分离的成人全心脏组织显示，在高血压患者心脏中，MEL18介导的HSF2-IGF-IIR途径上调。