Duque Cristina, Feske Steven K, Sorond Farzaneh A
Division of Stroke and Neurocritical Care, Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
Department of Neurology, Coimbra University Hospital Center, Coimbra, Portugal.
Semin Neurol. 2017 Dec;37(6):679-688. doi: 10.1055/s-0037-1608881. Epub 2017 Dec 21.
Sex and gender, as biological and social factors, significantly influence health outcomes. Among the biological factors, sex differences in vascular physiology may be one specific mechanism contributing to the observed differences in clinical presentation, response to treatment, and clinical outcomes in several vascular disorders. This review focuses on the cerebrovascular bed and summarizes the existing literature on sex differences in cerebrovascular hemodynamics to highlight the knowledge deficit that exists in this domain. The available evidence is used to generate mechanistically plausible and testable hypotheses to underscore the unmet need in understanding sex-specific mechanisms as targets for more effective therapeutic and preventive strategies.
作为生物学和社会因素，性别对健康结果有显著影响。在生物学因素中，血管生理的性别差异可能是导致在几种血管疾病的临床表现、治疗反应和临床结果方面观察到差异的一种特定机制。本综述聚焦于脑血管床，总结了关于脑血管血流动力学性别差异的现有文献，以突出该领域存在的知识空白。利用现有证据生成具有机制合理性且可检验的假设，以强调在理解性别特异性机制作为更有效治疗和预防策略靶点方面未得到满足的需求。
