Pathological Anatomy Research Lab, Beijing Tuberculosis and Thoracic Tumor Research Institute, Tongzhou, Beijing, China.
Eur Rev Med Pharmacol Sci. 2017 Dec;21(24):5691-5695. doi: 10.26355/eurrev_201712_14014.
The previous study found that long non-coding RNA LINC00261 (LINC00261) was significantly down-regulated in non-small cell lung cancer (NSCLC). However, the function of LINC00261 in the progression of NSCLC has not been reported. The present work aimed to explore the prognostic value of LINC00261 in patients with NSCLC.
The expression of LINC00261 was determined in NSCLC tissues and matched normal lung tissues by quantitative Real-time PCR (qRT-PCR). Furthermore, we evaluated the relationship of LINC00261 and clinicopathological features with survival of patients with NSCLC. Finally, univariate and multivariate Cox regression analyses were used to explore whether LINC00261 was an independent predictor of survival.
We found that the LINC00261 expression level in NSCLC tissues was suppressed compared with that in adjacent normal lung tissues (p < 0.01). Low expression of LINC00261 was found to significantly correlate with TNM stage (p = 0.005), lymph node status (p = 0.020), and distant metastasis (p = 0.004). Then, Kaplan-Meier analysis demonstrated that low LINC00261 expression level was associated with poorer overall survival (p = 0.0013). Furthermore, multivariate analysis showed that low expression of LINC00261 was an independent adverse prognostic factor of NSCLC (p = 0.004).
We firstly provided evidence that LINC00261 expression was associated with poor prognosis of NSCLC patients and may serve as an independent prognostic indicator.
先前的研究发现长链非编码 RNA LINC00261（LINC00261）在非小细胞肺癌（NSCLC）中显著下调。然而，LINC00261 在 NSCLC 进展中的功能尚未报道。本研究旨在探讨 LINC00261 在 NSCLC 患者中的预后价值。
通过定量实时 PCR（qRT-PCR）确定 NSCLC 组织和配对的正常肺组织中 LINC00261 的表达。此外，我们评估了 LINC00261 与临床病理特征与 NSCLC 患者生存的关系。最后，使用单因素和多因素 Cox 回归分析探讨 LINC00261 是否是生存的独立预测因子。
我们发现 NSCLC 组织中的 LINC00261 表达水平低于相邻的正常肺组织（p<0.01）。低表达 LINC00261 与 TNM 分期（p=0.005）、淋巴结状态（p=0.020）和远处转移（p=0.004）显著相关。然后，Kaplan-Meier 分析表明，低 LINC00261 表达水平与总生存期较差相关（p=0.0013）。此外，多因素分析表明，低表达 LINC00261 是 NSCLC 的独立不良预后因素（p=0.004）。
我们首次提供了证据表明 LINC00261 表达与 NSCLC 患者的不良预后相关，并且可能作为独立的预后指标。
