Zhang Menggang, Gao Fang, Yu Xiao, Zhang Qiyao, Sun Zongzong, He Yuting, Guo Wenzhi
Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital of Zhengzhou University, No. 1 Jianshedong Road, Erqi District, Zhengzhou, 450052, China.
Key Laboratory of Hepatobiliary and Pancreatic Surgery and Digestive Organ Transplantation of Henan Province, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China.
Cancer Cell Int. 2021 May 22;21(1):274. doi: 10.1186/s12935-021-01988-8.
Long noncoding RNAs (lncRNAs), are transcripts longer than 200 nucleotides that are considered to be vital regulators of many cellular processes, particularly in tumorigenesis and cancer progression. long intergenic non-protein coding RNA 261 (LINC00261), a recently discovered lncRNA, is abnormally expressed in a variety of human malignancies, including pancreatic cancer, gastric cancer, colorectal cancer, lung cancer, hepatocellular carcinoma, breast cancer, laryngeal carcinoma, endometrial carcinoma, esophageal cancer, prostate cancer, choriocarcinoma, and cholangiocarcinoma. LINC00261 mainly functions as a tumor suppressor that regulates a variety of biological processes in the above-mentioned cancers, such as cell proliferation, apoptosis, motility, chemoresistance, and tumorigenesis. In addition, the up-regulation of LINC00261 is closely correlated with both favorable prognoses and many clinical characteristics. In the present review, we summarize recent research documenting the expression and biological mechanisms of LINC00261 in tumor development. These findings suggest that LINC00261, as a tumor suppressor, has bright prospects both as a biomarker and a therapeutic target.
长链非编码RNA（lncRNAs）是长度超过200个核苷酸的转录本，被认为是许多细胞过程的重要调节因子，尤其是在肿瘤发生和癌症进展过程中。长链基因间非编码RNA 261（LINC00261）是一种最近发现的lncRNA，在多种人类恶性肿瘤中异常表达，包括胰腺癌、胃癌、结直肠癌、肺癌、肝细胞癌、乳腺癌、喉癌、子宫内膜癌、食管癌、前列腺癌、绒毛膜癌和胆管癌。LINC00261主要作为一种肿瘤抑制因子发挥作用，调节上述癌症中的多种生物学过程，如细胞增殖、凋亡、迁移、化疗耐药性和肿瘤发生。此外，LINC00261的上调与良好的预后和许多临床特征密切相关。在本综述中，我们总结了最近关于LINC00261在肿瘤发生中的表达和生物学机制的研究。这些发现表明，LINC00261作为一种肿瘤抑制因子，作为生物标志物和治疗靶点都具有广阔的前景。
