Department of Neurology, Huai'an First People's Hospital, Nanjing Medical University, Huai'an, Jiangsu, P.R. China.
Eur Rev Med Pharmacol Sci. 2017 Dec;21(24):5745-5750. doi: 10.26355/eurrev_201712_14021.
We aimed to compare the different non-motor symptoms of different motor phenotype Parkinson's disease (PD) at an early stage.
From January 2013 to November 2016, 120 cases of PD patients who were hospitalized in Neurology Department of the First Hospital of Huai'an in Jiangsu Province and 120 cases of healthy controls with matched age and gender, were included into the research. PD patients were administered with Non-Motor symptom questionnaire (NMSQuest), the Unified Parkinson's Disease Rating Scale III (UPDRS-III), the Mini-Mental State Examination score (MMSE), the Hoehn-Yahr classification, the MoCA, and GDS-15. The relationship between NMS burden and PD subtypes, age, gender and disease severity were examined using linear regression models. The prevalence of each NMS among different PD motor subtypes was analyzed using x2 test.
Compared with the healthy controls, PD patients had a higher number of NMS. The prevalence of NMS in postural instability gait difficulty (PIGD) group is higher than that in tremor dominant (TD) group. There is no significant correlation between age, gender, MMSE scores, MoCA scores and the number of NMS. PD patients with higher UPDRS-III scores and a longer course of disease had a higher prevalence of NMS.
NMS is also common in PD patients at an early stage. The PIGD group who have more axial injuries and more severe motor symptoms, have a higher risk of NMS burden than PD patients in TD group.
本研究旨在比较不同运动表型帕金森病（PD）患者在早期的不同非运动症状。
选取 2013 年 1 月至 2016 年 11 月在江苏省淮安市第一人民医院神经内科住院的 120 例 PD 患者和 120 例年龄和性别相匹配的健康对照者作为研究对象。PD 患者采用非运动症状问卷（NMSQuest）、统一帕金森病评定量表 III （UPDRS-III）、简易精神状态检查评分（MMSE）、Hoehn-Yahr 分级、蒙特利尔认知评估量表（MoCA）和老年抑郁量表（GDS-15）进行评估。采用线性回归模型分析 NMS 负担与 PD 亚型、年龄、性别和疾病严重程度的关系。采用卡方检验分析不同 PD 运动亚型中各 NMS 的患病率。
与健康对照组相比，PD 患者的 NMS 较多。姿势不稳步态困难（PIGD）组 NMS 的患病率高于震颤为主（TD）组。NMS 的患病率与年龄、性别、MMSE 评分、MoCA 评分无关。UPDRS-III 评分较高、病程较长的 PD 患者 NMS 患病率较高。
早期 PD 患者也存在 NMS。与 TD 组相比，PIGD 组有更多的轴性损伤和更严重的运动症状，NMS 负担的风险更高。
