Krevsky B, Libster B, Maurer A H, Chase B J, Fisher R S
Department of Medicine, Temple University School of Medicine, Philadelphia, PA 19140.
Life Sci. 1989;44(13):873-9. doi: 10.1016/0024-3205(89)90587-0.
The effects of endogenous and exogenous opioid substances on feline colonic transit were evaluated using colonic transit scintigraphy. Naloxone (0.3 mg/kg, i.m.) accelerated emptying of the cecum and ascending colon, and filling of the transverse colon. Endogenous opioid peptides thus appear to play a significant role in the regulation of colonic transit. At a moderate dose of morphine (0.1 mg/kg, i.m.), cecum and ascending colon transit was accelerated, while at a larger dose (1.0 mg/kg, i.m.) morphine had no effect. Since naloxone, a relatively nonspecific opioid antagonist, and morphine, a principally mu opioid receptor agonist, both accelerate proximal colonic transit, a decelerating role for at least one of the other opioid receptors is inferred.
使用结肠运输闪烁扫描法评估内源性和外源性阿片类物质对猫结肠运输的影响。纳洛酮（0.3毫克/千克，肌肉注射）加速了盲肠和升结肠的排空以及横结肠的充盈。因此，内源性阿片肽似乎在结肠运输的调节中起重要作用。中等剂量的吗啡（0.1毫克/千克，肌肉注射）可加速盲肠和升结肠的运输，而较大剂量（1.0毫克/千克，肌肉注射）的吗啡则无此作用。由于相对非特异性的阿片拮抗剂纳洛酮和主要作用于μ阿片受体的激动剂吗啡都能加速近端结肠运输，因此推断至少其他一种阿片受体具有减速作用。
