Krevsky B, Fisher R S, Cowan A
Department of Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania 19140.
Experientia. 1990 Feb 15;46(2):217-9. doi: 10.1007/BF02027320.
To determine whether the colonic transit accelerating effect of (-)-naloxone (0.3 mg/kg, i.m.) is due to an action at opioid receptors or a direct pharmacologic effect, its enantiomer, (+)-naloxone (0.3 mg/kg, i.m.), was administered to cats and compared to saline control using colonic transit scintigraphy. Transit was not accelerated by (+)-naloxone. The effects of naloxone on colonic transit are thus stereospecific, and are probably mediated by opioid receptors.
为了确定（-）-纳洛酮（0.3毫克/千克，肌肉注射）的结肠转运加速作用是由于其对阿片受体的作用还是直接的药理作用，将其对映体（+）-纳洛酮（0.3毫克/千克，肌肉注射）给予猫，并使用结肠转运闪烁扫描法与生理盐水对照组进行比较。（+）-纳洛酮并未加速转运。因此，纳洛酮对结肠转运的作用具有立体特异性，可能是由阿片受体介导的。
