McMillen I C, Jenkin G, Haji-Baba A S, Browne C A, Thorburn G D
Department of Physiology, Monash University, Clayton, Vic., Australia.
Life Sci. 1989;44(8):563-9. doi: 10.1016/0024-3205(89)90618-8.
We have measured circulating concentrations of gamma 3 Melanocyte Stimulating Hormone (MSH) in fetal sheep between 111 and 145 days gestation. There was no significant effect of gestational age on the fetal plasma concentrations of gamma 3 MSH throughout this period. We have examined the role of gamma-MSH related peptides in the control of fetal adrenal steroidogenesis and found no significant change in fetal plasma cortisol or pregnenolone concentrations during a 60-72 h infusion of saline, gamma 2 MSH or gamma 3 MSH in sheep between 130 and 135 days gestation. Therefore although we have demonstrated the presence of gamma MSH related peptides in fetal sheep plasma during late gestation we have failed to demonstrate a role for gamma 3 or gamma 2 MSH in the changes in fetal steroid concentrations which occur prepartum.
我们测量了妊娠111至145天的胎羊体内γ3促黑素细胞激素（MSH）的循环浓度。在此期间，胎龄对胎羊血浆γ3 MSH浓度没有显著影响。我们研究了γ-MSH相关肽在胎儿肾上腺类固醇生成控制中的作用，发现在妊娠130至135天的绵羊中，在输注生理盐水、γ2 MSH或γ3 MSH 60 - 72小时期间，胎羊血浆皮质醇或孕烯醇酮浓度没有显著变化。因此，尽管我们已经证明在妊娠晚期胎羊血浆中存在γ MSH相关肽，但我们未能证明γ3或γ2 MSH在产前发生的胎儿类固醇浓度变化中起作用。
