Gordon J H
Pharmacol Biochem Behav. 1983 Nov;19(5):807-11. doi: 10.1016/0091-3057(83)90085-0.
Seven days post-hypophysectomy female rats display a hyposensitivity to the locomotor effects of apomorphine and a hypersensitivity to the stereotypy effects of apomorphine, while at 28 days post-hypophysectomy they are hypersensitive to both the locomotor and stereotypy effects of apomorphine. The hyposensitivity to the locomotor effects, at 7 days post-hypophysectomy, was associated with a decrease in 3H-spiroperidol binding and an increase in tyrosine hydroxylase activity in the nucleus accumbens septi, whereas the hypersensitivity, at 28 days post-hypophysectomy, was associated with an increase in 3H-spiroperidol and a decrease in tyrosine hydroxylase activity in the n. accumbens septi. The increased apomorphine-induced stereotypy in both the 7 and 28 days post-hypophysectomized animals was related to an increased 3H-spiroperidol binding and a decreased tyrosine hydroxylase activity in the striatum. These behavioral and neurochemical data demonstrate that following hypophysectomy female rats will develop a transient decrease in dopamine receptor sensitivity in the n. accumbens septi, while the dopamine sensitivity in the striatum is increased. Thus the hypophysectomized female rat may prove to be a valuable model to study these two separate dopamine systems and their possible modulatory roles in the display of various behaviors.
垂体切除术后7天的雌性大鼠对阿扑吗啡的运动效应表现出低敏感性，而对阿扑吗啡的刻板效应表现出高敏感性，而在垂体切除术后28天，它们对阿扑吗啡的运动和刻板效应均表现出高敏感性。垂体切除术后7天对运动效应的低敏感性与伏隔核中3H-螺哌啶醇结合减少和酪氨酸羟化酶活性增加有关，而垂体切除术后28天的高敏感性与伏隔核中3H-螺哌啶醇增加和酪氨酸羟化酶活性降低有关。垂体切除术后7天和28天的动物中，阿扑吗啡诱导的刻板行为增加与纹状体中3H-螺哌啶醇结合增加和酪氨酸羟化酶活性降低有关。这些行为和神经化学数据表明，垂体切除术后雌性大鼠伏隔核中的多巴胺受体敏感性会出现短暂下降，而纹状体中的多巴胺敏感性会增加。因此，垂体切除的雌性大鼠可能是研究这两个独立的多巴胺系统及其在各种行为表现中可能的调节作用的有价值模型。
