Nanotechnology Institute, Amirkabir University of Technology, Tehran 15875-4413, Iran; Department of Textile Engineering, AmirKabir University of Technology, Tehran 15875-4413, Iran; Department of Stem Cells and Developmental Biology, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran.
Nanotechnology Institute, Amirkabir University of Technology, Tehran 15875-4413, Iran; Department of Textile Engineering, AmirKabir University of Technology, Tehran 15875-4413, Iran.
J Mech Behav Biomed Mater. 2018 Mar;79:38-45. doi: 10.1016/j.jmbbm.2017.12.012. Epub 2017 Dec 10.
Electrospun nanofiber matrices are widely used as scaffolds for the regeneration of different tissues due to similarities with fibrous components of the extracellular matrix. These scaffolds could act as a substrate for inducing mechanical stimuli to cells. The main mechanical stimuli factor in nanofiber scaffolds for determining the cell behaviors is stiffness of single nanofibers. This paper especially highlights the finding that the young's modulus of single nanofibers can be obtained from aligned nanofibers matrix. It is assume that, the modulus of single nanofibers are equal to modulus of completely aligned nanofibers. However, due to difficulty of producing completely aligned nanofibers, the obtained modulus of single nanofiber wouldn't have significant value. Therefore, we propose a new mathematical model to predict the stiffness of single nanofibers from non-perfectly aligned nanofibers matrix.
静电纺丝纳米纤维基质由于与细胞外基质的纤维成分相似，因此被广泛用作不同组织再生的支架。这些支架可以作为诱导细胞机械刺激的基底。在决定细胞行为的纳米纤维支架中，主要的机械刺激因素是单根纳米纤维的弹性模量。本文特别强调了一个发现，即可以从取向纳米纤维基质中获得单根纳米纤维的杨氏模量。假设单根纳米纤维的模量等于完全取向纳米纤维的模量。然而，由于完全取向纳米纤维的制备难度，得到的单根纳米纤维的模量将没有显著的价值。因此，我们提出了一个新的数学模型，用于从非完全取向的纳米纤维基质预测单根纳米纤维的刚度。
