Department of Pathophysiology, Third Military Medical University, Chongqing, People's Republic of China.
Institute of Immunology, People's Liberation Army (PLA), Third Military Medical University, Chongqing, People's Republic of China.
Semin Liver Dis. 2017 Nov;37(4):363-376. doi: 10.1055/s-0037-1607451. Epub 2017 Dec 22.
The transcription factor Yin Yang 1 (YY1) is a multifunctional protein that can activate or repress gene expression, depending on the cellular context. While YY1 is ubiquitously expressed and highly conserved between species, its role varies among the diverse cell types and includes proliferation, differentiation, and apoptosis. Upregulated YY1 expression is found in pathogenic conditions, such as human hepatocellular carcinoma and hepatitis B virus infection, and its roles in the molecular pathogenic mechanisms in liver (i.e., fibrosis, carcinogenesis, viral-induced injury) are currently being elucidated. The most recent studies have revealed that YY1 is deeply involved in such dysregulated cellular metabolisms as glycometabolism, lipid metabolism, and bile acid metabolism, which are all involved in various diseases. In this review, we will summarize the current knowledge on YY1 in liver diseases, providing a focused discussion on the characterized and probable underlying mechanisms, as well as a reasoned evaluation of the potential for YY1-mediated pathology as drug targets in liver disease therapies.
转录因子 Yin Yang 1（YY1）是一种多功能蛋白，可根据细胞环境激活或抑制基因表达。虽然 YY1 在物种间普遍表达且高度保守，但它在不同细胞类型中的作用不同，包括增殖、分化和凋亡。在肝炎病毒感染和人肝癌等病理条件下发现 YY1 表达上调，其在肝脏（如纤维化、癌变、病毒诱导损伤）中的分子发病机制中的作用目前正在阐明。最近的研究表明，YY1 深度参与糖代谢、脂代谢和胆汁酸代谢等失调的细胞代谢，这些代谢都与各种疾病有关。在这篇综述中，我们将总结 YY1 在肝脏疾病中的最新知识，重点讨论其特征和可能的潜在机制，并合理评估 YY1 介导的病理学作为肝脏疾病治疗药物靶点的潜力。
