Department of Clinical Virology, School of Medicine, University of Crete, Heraklio, Greece.
Cell Cycle. 2010 Feb 1;9(3):512-22. doi: 10.4161/cc.9.3.10588.
The Yin Yang 1 (YY1) transcription factor has been identified to target a plethora of potential target genes, the products of which are important for proliferation and differentiation. The mechanisms of YY1 action are related to its ability to initiate, activate or repress transcription depending on the context in which it binds. This article sheds a light on the role that YY1 plays in different human types of cancer, through the context of its expression levels. Moreover, we concentrate on the most relevant studies that have focused on YY1 regulation. we performed computational analysis on thirty-six publicly available Gene expression Omnibus (GeO) datasets, to further understand whether differences in YY1 transcript levels occur in different cancer types when compared with relative normal tissue, benign tumor or its metastatic counterpart. Our results suggest a dual role of YY1 in cancer development, either through overexpression or under-expression, depending on the tumor type.
阴阳 1（YY1）转录因子已被确定为靶向大量潜在靶基因，其产物对于增殖和分化很重要。YY1 作用的机制与其依赖于其结合的上下文启动、激活或抑制转录的能力有关。本文通过 YY1 表达水平的背景，阐明了 YY1 在不同人类类型癌症中的作用。此外，我们还集中讨论了最相关的研究，这些研究集中在 YY1 的调控上。我们对 36 个公开可用的基因表达综合数据库（GeO）数据集进行了计算分析，以进一步了解与相对正常组织、良性肿瘤或其转移对应物相比，YY1 转录本水平在不同癌症类型中是否存在差异。我们的结果表明，YY1 在癌症发展中具有双重作用，这取决于肿瘤类型，可能是通过过表达或低表达。
