一种来自马齿苋的异吲哚生物碱
An isoindole alkaloid from Portulaca oleracea L.
作者信息
Jiang Mingyue, Zhang Wenjie, Yang Xu, Xiu Fen, Xu Haoran, Ying Xixiang, Stien Didier
机构信息
a School of Pharmacy , Liaoning University of Traditional Chinese Medicine , Dalian , China.
b Laboratoire de Biodiversité et Biotechnologies Microbiennes (LBBM), Observatoire Océanologique , Sorbonne Universités, UPMC Univ Paris 06, CNRS , Banyuls-sur-Mer , France.
出版信息
Nat Prod Res. 2018 Oct;32(20):2431-2436. doi: 10.1080/14786419.2017.1419226. Epub 2017 Dec 22.
A novel isoindole alkaloid named oleraisoindole (1), together with six known compounds, 7'-ethoxy-trans-feruloyltyramine (2), N-trans-feruloyltyramine (3), N-trans-feruloyl-3-methoxytyramine (4), N-trans-p-coumaroyltyramine (5) aurantiamide (6) and ferulic acid methyl ester (7) were isolated from Portulaca oleracea L. Compounds 2 and 7 were isolated for the first time from this plant. Compound 1 was identified using spectroscopic methods including HR-ESI-TOF-MS, 1D-NMR, 2D-NMR. It was tested in a nitric oxide (NO) inhibition assay and was shown to inhibit NO production in RAW 264.7 cells induced by LPS.
从马齿苋中分离出一种名为马齿苋异吲哚（1）的新型异吲哚生物碱，以及六种已知化合物，7'-乙氧基-反式阿魏酰酪胺（2）、N-反式阿魏酰酪胺（3）、N-反式阿魏酰-3-甲氧基酪胺（4）、N-反式对香豆酰酪胺（5）、aurantiamide（6）和阿魏酸甲酯（7）。化合物2和7首次从该植物中分离得到。化合物1通过包括高分辨电喷雾电离飞行时间质谱（HR-ESI-TOF-MS）、一维核磁共振（1D-NMR）、二维核磁共振（2D-NMR）在内的光谱方法进行鉴定。它在一氧化氮（NO）抑制试验中进行了测试，结果表明其能抑制脂多糖（LPS）诱导的RAW 264.7细胞中NO的产生。
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