Department of Dermatology, University of California, San Francisco, California, USA; Veterans Affairs Medical Center, San Francisco, California, USA.
Department of Dermatology, University of California, San Francisco, California, USA.
J Invest Dermatol. 2018 Jan;138(1):16-17. doi: 10.1016/j.jid.2017.09.007.
In this issue, Albibas et al. investigate the mutational nature of p53-immunopositive patches, commonly observed in sun-damaged skin. p53-immunopositive patches have long been suspected to be lineal precursors to actinic keratoses and cutaneous squamous cell carcinomas. However, the mutations actually giving rise to p53-immunopositive patches, and their relationship to skin cancer, have never been defined. The considerable clinical and economic costs of monitoring and treating sun-damaged skin demand we better understand the evolution of these common premalignancies.
在本期杂志中，Albibas 等人研究了 p53 免疫阳性斑块的突变性质，这些斑块在日光损伤的皮肤中很常见。p53 免疫阳性斑块长期以来一直被怀疑是光化性角化病和皮肤鳞状细胞癌的线性前体。然而，实际上导致 p53 免疫阳性斑块的突变及其与皮肤癌的关系从未被定义过。监测和治疗日光损伤皮肤的巨大临床和经济成本要求我们更好地了解这些常见癌前病变的演变。
