Holden T J
Department of Psychiatry, Queen's University, Kingston, Ontario, Canada.
Med Hypotheses. 1989 Feb;28(2):109-13. doi: 10.1016/0306-9877(89)90023-6.
Schizophrenia is a disease of consciousness. The different neuroscientific disciplines have reported correlations with dysfunction and pathology at various levels in the hierarchy of biological explanation. A holistic model of schizophrenia is presented, developed from the premise that the neurophysiological correlate of consciousness is the cortical electrical interference pattern produced by the superimposition of the sensory event related potential on the basal alpha rhythm. The role of the Isodendritic Core of the Brain is discussed and the genesis of schizophrenic symptoms is related to post mortem histopathological findings that can be attributed to viral induced fibrillary gliosis.
精神分裂症是一种意识疾病。不同的神经科学学科报告了在生物学解释层次结构的各个层面上与功能障碍和病理学的相关性。本文提出了一种精神分裂症的整体模型，该模型基于这样一个前提：意识的神经生理相关物是感觉事件相关电位叠加在基础阿尔法节律上所产生的皮质电干扰模式。文中讨论了脑的等树突核心的作用，并且精神分裂症症状的成因与死后组织病理学发现相关，这些发现可归因于病毒诱导的纤维性胶质增生。
