An integrated neuropathophysiological model of schizophrenia.

Schizophrenia is a disease of consciousness. The different neuroscientific disciplines have reported correlations with dysfunction and pathology at various levels in the hierarchy of biological explanation. A holistic model of schizophrenia is presented, developed from the premise that the neurophysiological correlate of consciousness is the cortical electrical interference pattern produced by the superimposition of the sensory event related potential on the basal alpha rhythm. The role of the Isodendritic Core of the Brain is discussed and the genesis of schizophrenic symptoms is related to post mortem histopathological findings that can be attributed to viral induced fibrillary gliosis.