Kryst L, Wanyura H
J Maxillofac Surg. 1979 Nov;7(4):320-6. doi: 10.1016/s0301-0503(79)80058-2.
The study presents the clinical symptomatology of acute embolic-toxic reactions to penicillin seen in 9 patients treated with the drug. The complex of short-lasting symptoms characterized by severe agitation with confusion, visual and auditory hallucinations and dire fear is caused by accidental penetration of an amount of intramuscular penicillin injected into the venous system. The authors' experience and the data so far published reveal a much more frequent occurrence of Hoigné's (1959) syndrome than is usually thought. The syndrome does not depend upon the dose of a single injection of procaine penicillin but it may be attributed to poor technique of intramuscular injection and to great number of injections in a small area of the buttock. It is recommended that intravenous steroids in the treatment of acute symptoms of Hoigné's syndrome beside pharmacological sedation of the patient are applied.
该研究呈现了9例接受青霉素治疗的患者出现的急性栓塞性中毒反应的临床症状。由静脉注射进入静脉系统的一定量肌肉注射青霉素意外渗透所导致的一系列短暂症状，其特征为严重躁动伴意识混乱、视幻觉和极度恐惧。作者的经验以及迄今已发表的数据表明，霍伊内（1959年）综合征的发生频率比通常认为的要高得多。该综合征并不取决于单次注射普鲁卡因青霉素的剂量，而是可能归因于肌肉注射技术不佳以及在臀部小区域内多次注射。建议在对患者进行药物镇静的同时，应用静脉注射类固醇来治疗霍伊内综合征的急性症状。
