Department of Pathology, Busan Paik Hospital, Inje University College of Medicine, Busan, 47392, South Korea.
Department of Radiology, Busan Paik Hospital, Inje University College of Medicine, Busan, 47392, South Korea.
Endocr Pathol. 2018 Mar;29(1):30-34. doi: 10.1007/s12022-017-9508-1.
No published study has compared the cytological adequacy between different caliber needles in liquid-based cytology (LBC) after fine-needle aspiration (FNA) of thyroid nodules. This study aimed to compare cytological adequacy, pain scale, and associated complications depending on the use of a 21- and 23-gauge needle in LBC. From January 2017 to April 2017, 88 solid thyroid nodules (STNs) in 88 patients underwent consecutive ultrasonography (US)-guided FNA (US-FNA) by a single radiologist. The selection of the needle size was randomized and changed biweekly. After FNA, the pain scale and other complications related to FNA were immediately evaluated for each patient. In all cases, adequacy and cellularity in cytology were retrospectively investigated by a single cytopathologist. Of the 88 STNs, 10 (11.4%) showed inadequate cytology: 6 for 21-gauge and 4 for 23-gauge needles. The rate of cytological adequacy was higher in the 23-gauge needle group than in the 21-gauge group, but this was not statistically significant (p = 0.318). The mean values of the pain scale in the 21- and 23-gauge needle groups were 1.8 ± 1.3 and 1.4 ± 1.1, respectively, but this difference was not statistically significant (p = 0.567). There were no significant complications associated with US-FNA, except for one case of mild intrathyroidal hemorrhage. In US-FNA of STNs using LBC, the use of a 23-gauge needle may be recommended rather than a 21-gauge needle.
尚未有研究比较过甲状腺结节细针抽吸活检（FNA）后，在液体基细胞学（LBC）中不同规格的针之间的细胞学充分性。本研究旨在比较使用 21 号和 23 号针在 LBC 中的细胞学充分性、疼痛评分和相关并发症。
2017 年 1 月至 2017 年 4 月，88 例甲状腺实性结节（STN）患者接受了单名放射科医师连续进行的超声（US）引导下 FNA（US-FNA）。针的大小选择是随机的，每两周改变一次。FNA 后，立即对每位患者评估疼痛评分和与 FNA 相关的其他并发症。在所有情况下，由一名细胞病理学家回顾性调查细胞学的充分性和细胞数量。在 88 例 STN 中，有 10 例（11.4%）显示细胞学不充分：6 例为 21 号针，4 例为 23 号针。23 号针组的细胞学充分率高于 21 号针组，但无统计学意义（p=0.318）。21 号针和 23 号针组的疼痛评分均值分别为 1.8±1.3 和 1.4±1.1，但无统计学差异（p=0.567）。除 1 例轻度甲状腺内出血外，US-FNA 无明显相关并发症。在 LBC 中，使用 23 号针进行 STN 的 US-FNA 可能优于 21 号针。
