Rowley H A, Lowenstein D H, Rowbotham M C, Simon R P
Department of Neurology, University of California, San Francisco 94143.
Neurology. 1989 Mar;39(3):428-30. doi: 10.1212/wnl.39.3.428.
Three young patients developed strokes of rostral midbrain and thalamus shortly following cocaine abuse. Two had infarctions and one had a hemorrhage, but none had clear risk factors other than cocaine for this relatively uncommon type of stroke. Toxicologic analysis confirmed isolated cocaine use in each patient. In the two cases of infarction studied angiographically, one had normal findings and the other had focal narrowing of the P1 segments of the posterior cerebral arteries bilaterally. Since the P1 segment has a uniquely sparse perivascular sympathetic supply, we suggest that direct adrenergic-mediated vasoconstriction is not critical to the production of cocaine-associated stroke.
三名年轻患者在滥用可卡因后不久发生了中脑前部和丘脑的中风。两名患者发生梗死，一名患者发生出血，但除可卡因外，没有其他明显的危险因素导致这种相对罕见的中风类型。毒理学分析证实每名患者仅使用了可卡因。在进行血管造影研究的两例梗死病例中，一例结果正常，另一例双侧大脑后动脉P1段有局灶性狭窄。由于P1段的血管周围交感神经供应特别稀少，我们认为直接的肾上腺素能介导的血管收缩对可卡因相关性中风的发生并不关键。
