Masur H, Elger C E, Ludolph A C, Galanski M
Department of Neurology, University of Münster, FRG.
Neurology. 1989 Mar;39(3):432-3. doi: 10.1212/wnl.39.3.432.
A patient developed marked cerebellar atrophy after a single suicidal intoxication with 7 grams phenytoin. The clinical signs of cerebellar dysfunction subsided very slowly and incompletely within 18 months. We documented the cerebellar atrophy by CTs 4 weeks and 1 year after the intoxication, and we suggest that a single severe acute intoxication with phenytoin may directly cause cerebellar degeneration.
