Alioğlu Z, Sari A, Velioğlu S K, Ouml;zmenoğlu M
Department of Neurology, Karadeniz Technical University Medical School, Trabzon, Turkey.
J Neuroradiol. 2000 Mar;27(1):52-5.
A 25-year-old woman was admitted to our hospital with encephalopathy and clinical signs of cerebellar dysfunction. She had recently received an overdose of phenytoin. On admission, plasma phenytoin level was high (50 microg/ml, therapeutic range 10-20 mg/ml). Magnetic resonance imaging showed no signs of cerebellar atrophy. The patient's neurological condition improved rapidly after withdrawal of phenytoin. Eight months later, the neurological examination disclosed minimal cerebellar disorders and magnetic resonance imaging showed cerebellar atrophy. Cerebellar atrophy due to acute phenytoin intoxication is very unusual but few cases have been reported. The present clinical and radiological findings suggest that short-term phenytoin overdose alone may cause cerebellar atrophy.
一名25岁女性因脑病和小脑功能障碍的临床症状入院。她近期曾过量服用苯妥英钠。入院时，血浆苯妥英水平很高（50微克/毫升，治疗范围为10 - 20毫克/毫升）。磁共振成像未显示小脑萎缩迹象。停用苯妥英钠后，患者的神经状况迅速改善。八个月后，神经检查发现有轻微的小脑功能障碍，磁共振成像显示小脑萎缩。急性苯妥英钠中毒导致的小脑萎缩非常罕见，但已有少数病例报道。目前的临床和影像学发现表明，单纯短期苯妥英钠过量可能会导致小脑萎缩。
