俄罗斯老年人群中，根据认知表现分类的簇集蛋白基因两种多态性的等位基因、基因型和单倍型频率。
Frequencies of alleles, genotypes and haplotypes of two polymorphisms in the clusterin gene in the Russian elderly population categorized by cognitive performance.
作者信息
Bocharova Anna V, Vagaitseva Kseniya V, Makeeva Oksana A, Marusin Andrey V, Stepanov Vadim A
机构信息
Laboratory of Evolutionary Genetics, Institute of Medical Genetics, Tomsk National Medical Research Center, Tomsk, Russia.
Laboratory of Human Ontogenetics, Tomsk State University, Tomsk, Russia.
出版信息
Data Brief. 2017 Dec 16;16:775-779. doi: 10.1016/j.dib.2017.12.019. eCollection 2018 Feb.
This article contains data on the frequencies of alleles, genotypes and haplotypes of the single nucleotide polymorphisms (SNPs) rs2279590 and rs1532278 in the CLU gene in a cohort of normal elderly from the Russian population. The SNPs have been reported to be associated with Alzheimer's disease and cognitive functions in genome-wide and candidate genes association studies. Cognitive performance in sample set was estimated by the Montreal Cognitive Assessment (MoCA). The frequencies of alleles, genotypes and haplotypes of two SNPs were calculated in 3 groups: total sample set, sample set with MoCA score less than 21 (the first quartile) and group with MoCA score more than 24 (the fourth quartile).
本文包含俄罗斯人群正常老年人队列中CLU基因单核苷酸多态性（SNP）rs2279590和rs1532278的等位基因、基因型和单倍型频率数据。在全基因组和候选基因关联研究中，这些SNP已被报道与阿尔茨海默病及认知功能相关。样本集中的认知表现通过蒙特利尔认知评估量表（MoCA）进行评估。在3组中计算了两个SNP的等位基因、基因型和单倍型频率：总样本集、MoCA评分低于21（第一四分位数）的样本集以及MoCA评分高于24（第四四分位数）的组。
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