癌症中与干性相关的标志物
Stemness-Related Markers in Cancer.
作者信息
Zhao Wenxiu, Li Yvonne, Zhang Xun
机构信息
Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114.
Dana Farber cancer Institute and Harvard Medical School, Boston, Massachusetts 02115.
出版信息
Cancer Transl Med. 2017;3(3):87-95. doi: 10.4103/ctm.ctm_69_16. Epub 2017 Jun 8.
Abstract
Cancer stem cells (CSCs), with their self-renewal ability and multilineage differentiation potential, are a critical subpopulation of tumor cells that can drive tumor initiation, growth, and resistance to therapy. Like embryonic and adult stem cells, CSCs express markers that are not expressed in normal somatic cells and are thus thought to contribute towards a 'stemness' phenotype. This review summarizes the current knowledge of stemness-related markers in human cancers, with a particular focus on important transcription factors, protein surface markers and signaling pathways.
摘要
癌症干细胞（CSCs）具有自我更新能力和多谱系分化潜能，是肿瘤细胞中的一个关键亚群，可驱动肿瘤的起始、生长及对治疗产生抗性。与胚胎干细胞和成体干细胞一样，癌症干细胞表达正常体细胞中不表达的标志物，因此被认为有助于形成“干性”表型。本综述总结了目前关于人类癌症中干性相关标志物的知识，特别关注重要的转录因子、蛋白质表面标志物和信号通路。
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