Pancreatic Surgery Unit, Division of Surgery (KLINTEC) - Karolinska Institutet at Center for Digestive Diseases Karolinska University Hospital, Stockholm, Sweden.
Pancreatic Surgery Unit, Division of Surgery (KLINTEC) - Karolinska Institutet at Center for Digestive Diseases Karolinska University Hospital, Stockholm, Sweden; Digestive and Liver Diseases Unit - Sapienza University of Rome, Italy.
Pancreatology. 2018 Mar;18(2):204-207. doi: 10.1016/j.pan.2017.12.009. Epub 2017 Dec 19.
There are very few data in the current literature regarding the short- and long-term outcome of surgery for pediatric pancreatic tumors (PPT). No data are available on the impact of pancreatic surgery on the children's growth.
This is a retrospective cohort study on a consecutive series of pediatric/adolescent patients who underwent pediatric surgery at Karolinska University Hospital from January 2005 to July 2017.
Overall 14 pancreatic operations were performed in 13 patients. The median age was 11.4 years (range 3-15). Six pancreaticoduodenectomies (42.8%), 5 distal pancreatectomies (35.7%), and 3 enucleations (21.5%) were performed. The final histology revealed a solid pseudopapillary tumor in 9 cases (69.2%), neuroblastoma in 1 (7.7%), ganglioneuroma in 1 (7.7%), pancreatoblastoma in 1 (7.7%), and insulinoma in 1 (7.7%). Overall, 3 patients developed post-operative complications (23%). There was no peri-operative mortality. All patients are alive after a median follow-up time of 80 months. Exocrine insufficiency was detected post-operatively in 4 patients (30.7%) Endocrine insufficiency requiring insulin treatment developed in one patient (7.7%). No significant impact on growth was detected in any of the patients after pancreatic resection.
In our series, surgery performed for PPTs seems to be safe and effective. The effect of pancreatic surgery on children's growth does not seem to be significant.
目前的文献中关于儿童胰腺肿瘤（PPT）的短期和长期手术结果的数据非常少。关于胰腺手术对儿童生长的影响尚无数据。
这是一项回顾性队列研究，对 2005 年 1 月至 2017 年 7 月在卡罗林斯卡大学医院接受小儿/青少年外科手术的连续系列患儿进行了研究。
总共在 13 例患者中进行了 14 例胰腺手术。中位年龄为 11.4 岁（范围 3-15）。进行了 6 例胰十二指肠切除术（42.8%）、5 例胰体尾切除术（35.7%）和 3 例肿瘤剜除术（21.5%）。最终组织学显示 9 例（69.2%）为实性假乳头状瘤、1 例（7.7%）为神经母细胞瘤、1 例（7.7%）为节细胞神经瘤、1 例（7.7%）为胰腺母细胞瘤和 1 例（7.7%）为胰岛素瘤。总体而言，3 例患者发生术后并发症（23%）。无围手术期死亡。中位随访时间为 80 个月后所有患者均存活。4 例（30.7%）患者术后发生外分泌功能不全，1 例（7.7%）患者发生需要胰岛素治疗的内分泌功能不全。胰腺切除术后未发现任何患者的生长受到显著影响。
在我们的系列中，针对 PPT 进行的手术似乎是安全有效的。胰腺手术对儿童生长的影响似乎并不显著。
