Department of Abdominal Surgery, National Institute of Neoplastic Diseases INEN, Holbein Street 107, Lima, Perú.
Hepato-Biliary-Pancreatic Surgery Division, Department of Surgery, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Pediatr Surg Int. 2021 Aug;37(8):1041-1047. doi: 10.1007/s00383-021-04877-3. Epub 2021 Mar 19.
Pancreas tumors are extremely rare in pediatric and adolescent patients. Surgical resection is the mainstay of treatment; however, the data are limited with respect to morbidity and mortality. We aimed to evaluate short- and long-term outcomes of pediatric and adolescent patients who underwent surgical resection of pancreatic tumors.
Patients [Formula: see text] 18-year-olds who underwent resection of pancreas tumor at the National Institute of Neoplastic Diseases INEN during 2000-2020 were included.
Thirty-four patients were diagnosed; 28 patients were female and 6 were male. The median age was 13.4-years-old. Histological diagnosis was solid pseudopapillary neoplasm (SPN) (n = 29, 85.3%), pancreatoblastoma (n = 3), neuroendocrine carcinoma (n = 1), and insulinoma (n = 1). No patient experienced postoperative mortality and 15 (44.1%) patients developed postoperative complications including pancreatic fistula as the most frequent. Under a median follow-up period of 33.8 (0.5-138) months, four (11.8%) patients died. Of the 29 patients with SPN, the 3- and-5-year OS rates were 100% and 83.1%, respectively.
SPN was the most frequent cause of surgical treatment for pediatric and adolescent patients in the high-volume cancer center in Peru and was associated with favorable survival. Pancreaticoduodenectomy was safely performed in this patient group with acceptable morbidity and zero mortality.
胰腺肿瘤在儿科和青少年患者中极为罕见。手术切除是主要的治疗方法，但发病率和死亡率的数据有限。我们旨在评估接受胰腺肿瘤切除术的儿科和青少年患者的短期和长期结果。
纳入 2000 年至 2020 年在国家肿瘤疾病研究所 INEN 接受胰腺肿瘤切除术的[Formula: see text]18 岁的患者。
共诊断出 34 例患者，其中 28 例为女性，6 例为男性。中位年龄为 13.4 岁。组织学诊断为实性假乳头状瘤（SPN）（n=29，85.3%）、胰母细胞瘤（n=3）、神经内分泌癌（n=1）和胰岛素瘤（n=1）。无患者术后死亡，15 例（44.1%）患者发生术后并发症，其中最常见的是胰瘘。在中位随访 33.8（0.5-138）个月后，有 4 例（11.8%）患者死亡。在 29 例 SPN 患者中，3 年和 5 年 OS 率分别为 100%和 83.1%。
SPN 是秘鲁高容量癌症中心接受胰腺肿瘤切除术的儿科和青少年患者最常见的原因，且与良好的生存相关。该患者群体中安全实施了胰十二指肠切除术，发病率可接受，死亡率为零。
