Department of Cell and Molecular Biology, Karolinska Institute, Sweden; Department of Neurology, University Hospital Erlangen, Germany.
Department of Cell and Molecular Biology, Karolinska Institute, Sweden; DFG-Center for Regenerative Therapies Dresden, Technische Universität Dresden, Dresden, Germany.
EBioMedicine. 2018 Jan;27:176-181. doi: 10.1016/j.ebiom.2017.12.020. Epub 2017 Dec 19.
It is not known how long it takes from the initial neoplastic transformation of a cell to the detection of a tumor, which would be valuable for understanding tumor growth dynamics. Meningiomas show a broad histological, genetic and clinical spectrum, are usually benign and considered slowly growing. There is an intense debate regarding their age and growth pattern and when meningiomas should be resected. We have assessed the age and growth dynamics of 14 patients with meningiomas (WHO grade I: n=6 with meningothelial and n=6 with fibrous subtype, as well as n=2 atypical WHO grade II meningiomas) by combining retrospective birth-dating of cells by analyzing incorporation of nuclear-bomb-test-derived C, analysis of cell proliferation, cell density, MRI imaging and mathematical modeling. We provide an integrated model of the growth dynamics of benign meningiomas. The mean age of WHO grade I meningiomas was 22.1±6.5years, whereas atypical WHO grade II meningiomas originated 1.5±0.1years prior to surgery (p<0.01). We conclude that WHO grade I meningiomas are very slowly growing brain tumors, which are resected in average two decades after time of origination.
目前尚不清楚从细胞最初的肿瘤转化到肿瘤检测需要多长时间，这对于了解肿瘤生长动力学是有价值的。脑膜瘤具有广泛的组织学、遗传学和临床表现谱，通常为良性，被认为生长缓慢。关于脑膜瘤的年龄和生长模式以及何时应切除脑膜瘤存在激烈的争论。我们通过分析核爆试验衍生的 C 的掺入、细胞增殖、细胞密度、MRI 成像和数学建模来评估 14 例脑膜瘤（WHO 分级 I：脑膜内皮型 6 例和纤维型 6 例，以及 2 例非典型 WHO 分级 II 脑膜瘤）患者的年龄和生长动态。我们提供了良性脑膜瘤生长动力学的综合模型。WHO 分级 I 脑膜瘤的平均年龄为 22.1±6.5 岁，而非典型 WHO 分级 II 脑膜瘤在手术前 1.5±0.1 年前起源（p<0.01）。我们的结论是，WHO 分级 I 脑膜瘤是生长非常缓慢的脑肿瘤，平均在起源后二十年进行切除。
