Department of Clincal Laboratory, The First Hospital of Lanzhou University, West Road No. 1 East Hills, Chengguan District, Lanzhou, 730000, Gansu Province, PR China; The First Clinical College of Lanzhou University, West Road No. 1 East Hills, Chengguan District, Lanzhou, 730000, Gansu Province, PR China.
School of Material Science and Technology, Lanzhou University of Technology, Langongping Road, Lanzhou 730050, Gansu Province, PR China.
Prog Biophys Mol Biol. 2018 May;134:44-49. doi: 10.1016/j.pbiomolbio.2017.12.005. Epub 2017 Dec 24.
Bone remodeling is a persistent process for maintaining skeletal system homeostasis, and it depends on the dynamic equilibrium between bone-forming osteoblasts and bone-resorbing osteoclasts. Aryl hydrocarbon receptor (Ahr), a ligand-activated transcription factor, plays a pivotal role in regulating skeletal system. In order to better understand the role of Ahr in bone remodeling, we focused on bone remodeling characteristic, and the effects of Ahr on bone formation and differentiation, which suggest that Ahr is a critical control factor in the process of bone remodeling. Moreover, we discussed the impacts of Ahr on several signaling pathways related to bone remodeling, hoping to provide a theoretical basis to improve bone remodeling.
骨重建是维持骨骼系统内稳态的持续过程，依赖于成骨细胞和破骨细胞之间的动态平衡。芳香烃受体（Ahr）是一种配体激活的转录因子，在调节骨骼系统中发挥着关键作用。为了更好地理解 Ahr 在骨重建中的作用，我们重点研究了骨重建的特征，以及 Ahr 对骨形成和分化的影响，这表明 Ahr 是骨重建过程中的关键控制因素。此外，我们还讨论了 Ahr 对与骨重建相关的几种信号通路的影响，希望为改善骨重建提供理论基础。
