Department of Trauma and Reconstructive Surgery, BG Trauma Clinic, Siegfried Weller Institute for Trauma Research, Eberhard Karls University Tuebingen, 72076 Tuebingen, Germany.
Department of Orthopedics, Xiangya Hospital, Central South University, Changsha 410008, China.
Genes (Basel). 2022 Apr 30;13(5):806. doi: 10.3390/genes13050806.
Cigarette smoking (CS) leads to significant bone loss, which is recognized as an independent risk factor for osteoporosis. The number of smokers is continuously increasing due to the addictive nature of smoking. Therefore it is of great value to effectively prevent CS-induced osteoporosis. However, there are currently no effective interventions to specifically counteract CS-induced osteoporosis, owing to the fact that the specific mechanisms by which CS affects bone metabolism are still elusive. This review summarizes the latest research findings of important pathways between CS exposure and bone metabolism, with the aim of providing new targets and ideas for the prevention of CS-induced osteoporosis, as well as providing theoretical directions for further research in the future.
吸烟会导致明显的骨质流失，这被认为是骨质疏松症的一个独立危险因素。由于吸烟具有成瘾性，吸烟人数持续增加。因此，有效预防吸烟引起的骨质疏松症具有重要意义。然而，由于吸烟影响骨代谢的确切机制仍不清楚，目前还没有专门针对吸烟引起的骨质疏松症的有效干预措施。本综述总结了吸烟暴露与骨代谢之间重要途径的最新研究结果，旨在为预防吸烟引起的骨质疏松症提供新的靶点和思路，并为今后的进一步研究提供理论方向。
