Russell L C
Department of Surgery, Duke University Medical Center, Durham, N.C.
Nurse Pract. 1989 Feb;14(2):36-7, 40.
The effects of methylxanthines (caffeine, theophylline and theobromine) on the symptoms associated with fibrocystic breast disease were studied in 147 patients. Disease was documented by mammography, physical examination and clinical symptoms. Only those individuals with breast pain (n = 138) were included in the study. Questionnaires were presented and explained to all patients by the same nurse examiner. Patients reported their degree of caffeine consumption as either light (two cups per day or less of caffeine-containing beverages or foods), moderate (more than two cups, but less than six cups per day), or heavy (six cups per day or more of caffeine-containing products). They additionally reported breast pain as mild, moderate or severe. Past medical and family histories were reported as well as medication intake. All patients were counseled to abstain from or reduce caffeine consumption and were given a list of commonly used caffeine-containing products. The results at the end of one year indicated that compliance was high, with 113 patients (81.9 percent) reducing their caffeine intake substantially and, of those, 69 (61 percent) reporting a decrease or absence of breast pain. This study supports the findings of others in that caffeine restriction is an effective means of management of breast pain associated with fibrocystic disease.
对147名患者研究了甲基黄嘌呤（咖啡因、茶碱和可可碱）对与纤维囊性乳腺病相关症状的影响。通过乳房X光检查、体格检查和临床症状记录病情。只有那些有乳房疼痛的个体（n = 138）被纳入研究。由同一名护士检查员向所有患者发放并解释问卷。患者报告其咖啡因摄入量为轻度（每天两杯或更少含咖啡因的饮料或食物）、中度（每天超过两杯但少于六杯）或重度（每天六杯或更多含咖啡因的产品）。他们还报告了乳房疼痛为轻度、中度或重度。报告了既往病史和家族史以及药物摄入情况。所有患者均被建议戒除或减少咖啡因摄入，并得到一份常用含咖啡因产品清单。一年结束时的结果表明依从性很高，113名患者（81.9%）大幅减少了咖啡因摄入量，其中69名（61%）报告乳房疼痛减轻或消失。本研究支持其他研究的结果，即限制咖啡因摄入是管理与纤维囊性疾病相关的乳房疼痛的有效方法。
