Boyle C A, Berkowitz G S, LiVolsi V A, Ort S, Merino M J, White C, Kelsey J L
J Natl Cancer Inst. 1984 May;72(5):1015-9.
In a hospital-based case-control study that included 634 women with fibrocystic breast disease and 1,066 comparison women in Connecticut, the occurrence of fibrocystic breast disease was positively associated with average daily consumption of caffeine. Women who consumed 31-250 mg of caffeine/day had a 1.5-fold increase in the odds of disease, whereas women who drank over 500 mg/day had a 2.3-fold increase in the odds. The association with caffeine consumption was especially high among women with atypical lobular hyperplasia and with sclerosing adenosis with concomitant papillomatosis or papillary hyperplasia, both of which have been associated with an increased breast cancer risk. The association was specific to fibrocystic breast disease in that there was no association of caffeine consumption with fibroadenoma or other forms of benign breast disease.
在一项基于医院的病例对照研究中，研究对象包括康涅狄格州的634名患有纤维囊性乳腺病的女性和1066名对照女性。纤维囊性乳腺病的发生与咖啡因的日均摄入量呈正相关。每天摄入31 - 250毫克咖啡因的女性患该病的几率增加了1.5倍，而每天饮用超过500毫克咖啡因的女性患该病的几率增加了2.3倍。在患有非典型小叶增生以及伴有乳头状瘤病或乳头状增生的硬化性腺病的女性中，与咖啡因摄入的关联尤为显著，而这两种情况都与乳腺癌风险增加有关。这种关联是纤维囊性乳腺病所特有的，因为咖啡因摄入与纤维腺瘤或其他形式的良性乳腺病并无关联。
