癌症干细胞标志物对结肠肝转移瘤切除术后长期预后的预测作用

The Prognostic Role of Cancer Stem Cell Markers for Long-term Outcome After Resection of Colonic Liver Metastases.

作者信息

Spelt Lidewij, Sasor Agata, Ansari Daniel, Hilmersson Katarzyna Said, Andersson Roland

机构信息

Department of Surgery, Clinical Sciences Lund, Lund University and Skåne University Hospital, Lund, Sweden

Department of Pathology, Skåne University Hospital, Lund, Sweden.

出版信息

Anticancer Res. 2018 Jan;38(1):313-320. doi: 10.21873/anticanres.12224.

DOI:10.21873/anticanres.12224

PMID:29277789

Abstract

BACKGROUND/AIM: To assess the expression of cancer stem cell (CSC) markers CD44, CD133 and CD24 in colon cancer liver metastases and analyse their predictive value for overall survival (OS) and disease-free survival (DFS) after liver resection.

MATERIALS AND METHODS

Patients operated on for colon cancer liver metastases were included. CSC marker expression was determined through immunohistochemistry analysis. OS and DFS were compared between marker-positive and marker-negative patients. Multivariate analysis was performed to select predictive variables for OS and DFS.

RESULTS

CD133-positive patients had a worse DFS than CD133-negative patients, with a median DFS of 12 and 25 months (p=0.051). Multivariate analysis selected CD133 expression as a significant predictor for DFS. CD44 and CD24 were not found to predict OS or DFS.

CONCLUSION

CD133 expression in colonic liver metastases is a negative prognostic factor for DFS after liver resection. In the future, CD133 could be used as a biomarker for risk stratification, and possibly for developing novel targeted therapy.

摘要

背景/目的：评估癌症干细胞（CSC）标志物CD44、CD133和CD24在结肠癌肝转移灶中的表达，并分析其对肝切除术后总生存期（OS）和无病生存期（DFS）的预测价值。