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保留雷氏间隙的机器人辅助根治性前列腺切除术与较少的膀胱颈下移及更好的早期控尿结果相关。

Retzius-sparing Robotic-assisted Radical Prostatectomy Associated with Less Bladder Neck Descent and Better Early Continence Outcome.

作者信息

Chang Li-Wen, Hung Sheng-Chun, Hu Ju-Chuan, Chiu Kun-Yuan

机构信息

Division of Urology, Department of Surgery, Taichung Veterans General Hospital, Taichung, Taiwan, R.O.C.

Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan, R.O.C.

出版信息

Anticancer Res. 2018 Jan;38(1):345-351. doi: 10.21873/anticanres.12228.

Abstract

BACKGROUND/AIM: We attempted to evaluate the association of early continence outcome of Retzius-sparing robotic assisted radical prostatectomy (RARP) and bladder neck descent with postoperative cystography.

PATIENTS AND METHODS

From November 2014 to December 2015, 30 patients with prostate cancer who received Retzius-sparing LRP/ RARP were compared to 30 patients that received retropubic approach RARP with propensity score matching analysis. Cystogram was used to evaluate the bladder neck descent using the bladder neck to pubic symphysis (BNPS) ratio and the continence state was evaluated.

RESULTS

A total 60 patients were included 30 of which had received Retzius-sparing and 30 the retropubic approach, using propensity score matching analysis. There was no difference in age, prostate size, pathology T stage and PSA among groups. BNPS ratio is significantly low in the Retzius-sparing group (0.25±0.10 vs. 0.46±0.14, p=0.000). Early continence was improved in the Retzius-sparing group and early continence within the first week was 73.3% compared to 26.7% (p=0.000), but no difference was seen at one year (100.0% vs. 93.30%, p=0.150). The independent risk factors affecting post-operative continence were age and approach. The association between less bladder neck descent as BNP ratio and continence was also confirmed (HR=0.048, 95%CI=0.005-0.420, p=0.006).

CONCLUSION

With the advantage of more normal pelvic anatomy preserved in Retzius-sparing RARP, it was associated with less bladder neck descent and better early continence outcome. Age was also an independent risk factor for postoperative continence.

摘要

背景/目的:我们试图通过术后膀胱造影评估保留Retzius间隙的机器人辅助根治性前列腺切除术(RARP)的早期控尿结果与膀胱颈下移之间的关联。

患者与方法

2014年11月至2015年12月,将30例接受保留Retzius间隙的腹腔镜根治性前列腺切除术/机器人辅助根治性前列腺切除术(LRP/RARP)的前列腺癌患者与30例接受耻骨后入路机器人辅助根治性前列腺切除术的患者进行倾向评分匹配分析。使用膀胱造影通过膀胱颈至耻骨联合(BNPS)比率评估膀胱颈下移情况,并评估控尿状态。

结果

通过倾向评分匹配分析,共纳入60例患者,其中30例接受保留Retzius间隙手术,30例接受耻骨后入路手术。各组间年龄、前列腺大小、病理T分期和前列腺特异性抗原(PSA)无差异。保留Retzius间隙组的BNPS比率显著较低(0.25±0.10 vs. 0.46±0.14,p = 0.000)。保留Retzius间隙组的早期控尿情况得到改善,术后第一周的早期控尿率为73.3%,而另一组为26.7%(p = 0.000),但一年时两组无差异(100.0% vs. 93.30%,p = 0.150)。影响术后控尿的独立危险因素为年龄和手术入路。还证实了较低的膀胱颈下移(以BNP比率衡量)与控尿之间的关联(风险比[HR]=0.048,95%置信区间[CI]=0.005 - 0.420,p = 0.006)。

结论

保留Retzius间隙的机器人辅助根治性前列腺切除术具有保留更正常盆腔解剖结构的优势,与较少的膀胱颈下移和更好的早期控尿结果相关。年龄也是术后控尿的独立危险因素。

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