Bacalbasa Nicolae, Balescu Irina, Brasoveanu Vladislav, Anca Alexandru Florin
"Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania.
"Ponderas Academic Hospital", Bucharest, Romania
Anticancer Res. 2018 Jan;38(1):423-426. doi: 10.21873/anticanres.12239.
Gestational choriocarcinomas are very rare malignancies, with only few cases being reported so far. Moreover, the presence of pelvic recurrences after surgically-treated gestational choriocarcinomas is even scarcer situations. We present the case of a 19-year-old patient who was initially submitted to surgery with preoperative diagnosis of ectopic pregnancy. At that moment a left salpingectomy was performed, and the histopathological studies revealed the presence of a left tubal gestational choriocarcinoma. The patient was submitted to adjuvant chemotherapy with methotrexate and dactinomycin. However, six months later she was diagnosed with a pelvic recurrence so she was resubmitted to surgery, debulking to no residual disease being successfully performed. The histopathological studies confirmed the presence of a recurrent tumor with gestational choriocarcinoma structure.
妊娠性绒毛膜癌是非常罕见的恶性肿瘤,迄今为止仅有少数病例报道。此外,手术治疗后的妊娠性绒毛膜癌出现盆腔复发的情况更为罕见。我们报告一例19岁患者,最初因术前诊断为异位妊娠而接受手术。当时进行了左侧输卵管切除术,组织病理学研究显示存在左侧输卵管妊娠性绒毛膜癌。该患者接受了甲氨蝶呤和放线菌素D的辅助化疗。然而,六个月后她被诊断为盆腔复发,因此再次接受手术,成功地进行了肿瘤减灭术,无残留病灶。组织病理学研究证实存在具有妊娠性绒毛膜癌结构的复发性肿瘤。