乙型肝炎病毒C基因型在缅甸占主导地位。
Hepatitis B Virus Genotype C is Predominant in Myanmar.
作者信息
Nwe Win Nan, Nakamoto Shingo, Myint Sein Myint, Moriyama Mitsuhiko, Kanda Tatsuo, Shirasawa Hiroshi
机构信息
Department of Molecular Virology, Graduate School of Medicine, Chiba University, Inohana 1-8-1, Chuo-ku, Chiba 260-8677, Japan.
Division of Gastroenterology and Hepatology, Department of Medicine, Nihon University School of Medicine, 30-1 Oyaguchi-Kamicho, Itabashi-ku, Tokyo 173-8610, Japan.
出版信息
Diseases. 2017 Dec 26;6(1):3. doi: 10.3390/diseases6010003.
Myanmar is adjacent to India, Bangladesh, Thailand, Laos and China. In Myanmar, the prevalence of hepatitis B virus (HBV) infections is 6.5% and accounts for 60% of hepatocellular carcinoma. HBV has nine genotypes that have been identified by molecular genetic analysis. HBV genotypes are associated with several clinical features. We reviewed the prevalence of HBV genotypes in Myanmar and neighboring countries. We also reviewed HBV genotypes in refugees from Myanmar. HBV subgenotype C1 is predominant in Myanmar. As HBV genotype C is associated with hepatocellular carcinoma (HCC), it is important to screen for cirrhosis and HCC and to prevent their development in HBV-infected individuals of Myanmar.
缅甸与印度、孟加拉国、泰国、老挝和中国接壤。在缅甸，乙型肝炎病毒（HBV）感染的流行率为6.5%，占肝细胞癌的60%。通过分子遗传分析已鉴定出HBV有9种基因型。HBV基因型与多种临床特征相关。我们回顾了缅甸及周边国家HBV基因型的流行情况。我们还回顾了来自缅甸的难民中的HBV基因型。HBV C1亚型在缅甸占主导地位。由于HBV C基因型与肝细胞癌（HCC）相关，因此对缅甸HBV感染个体进行肝硬化和HCC筛查并预防其发展非常重要。
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